Effect of mercuric chloride on circulating hormones in adult albino rats

V. Ramalingam, V. Vimaladevi, S. Rajeswary, V. Suryavathi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The effect of mercuric chloride at two different doses, 0.5 mg/kg body weight (low dose), 1 mg/kg body weight (high dose), for 30 days, was seen on the circulating hormones in the mature male albino rats. Testosterone level was markedly decreased in the low dose (P< 0.01) and high dose (P< 0.001) treated animals. The level of luteinizing hormone (LH) was also reduced in the low dose (P< 0.01) as well as in the high dose (P< 0.001) treated animals. However, follicle stimulating hormone (FSH) and prolactin (PRL) levels were found to be decreased only in the high dose (P< 0.05) treated animals and no change was observed in the low dose. treated animals. The changes in the hormone levels caused by the mercuric chloride treatment suggest the dysfunction of pituitary-testicular axis.

Original languageEnglish (US)
Pages (from-to)401-404
Number of pages4
JournalJournal of Environmental Biology
Volume24
Issue number4
StatePublished - Oct 2003
Externally publishedYes

Keywords

  • FSH
  • LH
  • Mercuric chloride
  • Prolactin
  • Rat
  • Testosterone

ASJC Scopus subject areas

  • Environmental Engineering
  • Toxicology
  • Health, Toxicology and Mutagenesis

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