Effect of maternal nicotine on the development of sites for [3H]nicotine binding in the fetal brain

N. Hagino, J. W. Lee

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


The sites for [3H]nicotine binding in fetal brains were examined after administration of nicotine into pregnant rats. Administration of unlabelled nicotine into the pregnant rats increased Bmax values for the sites for [3H]nicotine binding without affecting Kd values in the fetal brains. Treatment with this regimen, however, did not show any significant change in the sites for [3H]quinuclidinyl benzylate (QNB) binding. In addition, treatment with this regimen increased Bmax values of the sites for [3H]nicotine binding in the brains of pregnant rats. α-Bungarotoxin had no effect on the sites for [3H]nicotine binding. It is inferred, therefore, that a similar response is elicited by nicotine binding sites to administered nicotine in both the fetal and maternal brains. Furthermore, a possible effect of nicotine in pregnant rats may be the facilitation of the development of nicotine acetylcholine receptors in the fetal brain.

Original languageEnglish (US)
Pages (from-to)567-571
Number of pages5
JournalInternational Journal of Developmental Neuroscience
Issue number5
StatePublished - 1985
Externally publishedYes


  • Brain
  • Fetuses
  • Nicotine
  • Rat
  • Receptors

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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