@article{d1f6f77944d84746ae23f51a2f986bff,
title = "Effect of maternal ethanol ingestion at two dietary levels of zinc on molar composition and dental caries of rat off spring",
abstract = "Pregnant rats were fed liquid diets containing either 2 or 10 μg Zn/ml with or without 30% of kcal from ethanol throughout gestation and lactation. At day 20 of lactation, three male rats from each litter were orally inoculated with Streptococcus mutans and fed a high sucrose-containing diet for six weeks. Maternal ethanol ingestion coinciding with offspring molar development significantly increased offspring dental caries scores and reduced the zinc content of enamel and dentin. Ethanol did not affect molar content of calcium, magnesium or phosphorus which suggests that ethanol is a specific antagonist of zinc utilization during molar development. Ethanol-antagonized zinc content of enamel may be responsible for the development of faulty enamel which has greater susceptibility to acid attack.",
keywords = "Alcohol, Caries, Ethanol, zinc",
author = "Yeh, {Lee Chuan C.} and Cerklewski, {Florian L.} and Alfred Soeldner",
note = "Funding Information: In the present study, we describe the effects of this interaction between ethanol and zinc on molar composition and subsequent susceptibility of offspring to dental caries during a post-weaning test period. There are several reasons for considering this study. Ethanol consumption during human pregnancy has been shown to produce offspring with smaller teeth and faulty enamel iTaken in part from a thesis submitted by L.-C. C. Yeh to Oregon State 2University in partial fulfillment of the requirements for a doctorate degree. Supported by NIH (NIDR) DE 05628 and the Oregon Agricultural Experiment 3Station, technical paper no. 7374. Present address: University of Texas Health Science Center, Department of 4Pharmacology, Division of Molecular Pharmacology, San Antonio, TX 78284. To whom reprint requests should be addressed. 5Director of the Electron Microscopy Facility at Oregon State University.",
year = "1985",
month = sep,
doi = "10.1016/S0271-5317(85)80109-3",
language = "English (US)",
volume = "5",
pages = "951--957",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "9",
}