Abstract
Background: Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months. Methods: Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation. Results: Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups. Conclusions: Mismatch produces sexually dimorphic post-natal growth phenotypes.
Original language | English (US) |
---|---|
Pages (from-to) | 226-235 |
Number of pages | 10 |
Journal | Journal of medical primatology |
Volume | 48 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2019 |
Externally published | Yes |
Keywords
- ACTH
- baboon
- catch-up growth
- cortisol
- developmental programing
- high-fat diet
- maternal nutrition
- mismatch
- non-human primates
- undernutrition
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)