Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post-natal offspring early life phenotype

Cun Li, Susan Jenkins, Hillary F. Huber, Peter W. Nathanielsz

Research output: Contribution to journalArticle

Abstract

Background: Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months. Methods: Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation. Results: Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups. Conclusions: Mismatch produces sexually dimorphic post-natal growth phenotypes.

Original languageEnglish (US)
Pages (from-to)226-235
Number of pages10
JournalJournal of medical primatology
Volume48
Issue number4
DOIs
StatePublished - Aug 2019
Externally publishedYes

Keywords

  • ACTH
  • baboon
  • catch-up growth
  • cortisol
  • developmental programing
  • high-fat diet
  • maternal nutrition
  • mismatch
  • non-human primates
  • undernutrition

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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