Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations

Sharon L. Lewis, Susan G. Kutvirt, Peter N. Bonner, Toby L. Simon

Research output: Contribution to journalArticle

Abstract

Previous studies of changes in immune function in platelet donors have investigated subjects who were undergoing plateletpheresis using older equipment that is no longer in general use. Therefore, the purpose of this study was to determine the effect of long-term platelet donation on lymphocyte numbers and subsets and plasma protein concentrations in platelet donors using newer cell separators. Three groups included in the study were nondonor controls (n=27), long-term whole blood donors (n=29), and long-term platelet donors (n=20). Using a cross-sectional analysis, lymphocyte numbers and subsets were determined and compared among the three groups. Plasma concentrations of total protein, globulin, albumin, and IgG were also compared. Among the three groups there were no significant differences in total white blood cell counts, percentage or absolute number of lymphocytes, or percentage or absolute number of lymphocyte subsets. Serum total protein, globulin, albumin, and IgG concentrations of platelet donors were within normal ranges. These data support the current Food and Drug Administration (FDA) and American Association of Blood Banks' standards for the frequency of platelet donation allowed and monitoring required for plateletpheresis donors. Furthermore, these data indicate that the FDA could eliminate the requirement for the warning in informed consents about lymphocyte depletion in platelet donors.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalTransfusion and Apheresis Science
Volume18
Issue number2
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Lymphocyte Subsets
Blood Proteins
Blood Platelets
Tissue Donors
Lymphocyte Count
Plateletpheresis
Globulins
United States Food and Drug Administration
Albumins
Immunoglobulin G
Lymphocyte Depletion
Blood Donors
Informed Consent
Leukocyte Count
Reference Values
Cross-Sectional Studies
Equipment and Supplies
Proteins

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this

Lewis, S. L., Kutvirt, S. G., Bonner, P. N., & Simon, T. L. (1997). Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations. Transfusion and Apheresis Science, 18(2), 205-213.

Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations. / Lewis, Sharon L.; Kutvirt, Susan G.; Bonner, Peter N.; Simon, Toby L.

In: Transfusion and Apheresis Science, Vol. 18, No. 2, 06.1997, p. 205-213.

Research output: Contribution to journalArticle

Lewis, SL, Kutvirt, SG, Bonner, PN & Simon, TL 1997, 'Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations', Transfusion and Apheresis Science, vol. 18, no. 2, pp. 205-213.
Lewis, Sharon L. ; Kutvirt, Susan G. ; Bonner, Peter N. ; Simon, Toby L. / Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations. In: Transfusion and Apheresis Science. 1997 ; Vol. 18, No. 2. pp. 205-213.
@article{d2a57f6cf67d4295a8f55eaf3ff628bd,
title = "Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations",
abstract = "Previous studies of changes in immune function in platelet donors have investigated subjects who were undergoing plateletpheresis using older equipment that is no longer in general use. Therefore, the purpose of this study was to determine the effect of long-term platelet donation on lymphocyte numbers and subsets and plasma protein concentrations in platelet donors using newer cell separators. Three groups included in the study were nondonor controls (n=27), long-term whole blood donors (n=29), and long-term platelet donors (n=20). Using a cross-sectional analysis, lymphocyte numbers and subsets were determined and compared among the three groups. Plasma concentrations of total protein, globulin, albumin, and IgG were also compared. Among the three groups there were no significant differences in total white blood cell counts, percentage or absolute number of lymphocytes, or percentage or absolute number of lymphocyte subsets. Serum total protein, globulin, albumin, and IgG concentrations of platelet donors were within normal ranges. These data support the current Food and Drug Administration (FDA) and American Association of Blood Banks' standards for the frequency of platelet donation allowed and monitoring required for plateletpheresis donors. Furthermore, these data indicate that the FDA could eliminate the requirement for the warning in informed consents about lymphocyte depletion in platelet donors.",
author = "Lewis, {Sharon L.} and Kutvirt, {Susan G.} and Bonner, {Peter N.} and Simon, {Toby L.}",
year = "1997",
month = "6",
language = "English (US)",
volume = "18",
pages = "205--213",
journal = "Transfusion and Apheresis Science",
issn = "1473-0502",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Effect of Long-term Platelet Donation on Lymphocyte Subsets and Plasma Protein Concentrations

AU - Lewis, Sharon L.

AU - Kutvirt, Susan G.

AU - Bonner, Peter N.

AU - Simon, Toby L.

PY - 1997/6

Y1 - 1997/6

N2 - Previous studies of changes in immune function in platelet donors have investigated subjects who were undergoing plateletpheresis using older equipment that is no longer in general use. Therefore, the purpose of this study was to determine the effect of long-term platelet donation on lymphocyte numbers and subsets and plasma protein concentrations in platelet donors using newer cell separators. Three groups included in the study were nondonor controls (n=27), long-term whole blood donors (n=29), and long-term platelet donors (n=20). Using a cross-sectional analysis, lymphocyte numbers and subsets were determined and compared among the three groups. Plasma concentrations of total protein, globulin, albumin, and IgG were also compared. Among the three groups there were no significant differences in total white blood cell counts, percentage or absolute number of lymphocytes, or percentage or absolute number of lymphocyte subsets. Serum total protein, globulin, albumin, and IgG concentrations of platelet donors were within normal ranges. These data support the current Food and Drug Administration (FDA) and American Association of Blood Banks' standards for the frequency of platelet donation allowed and monitoring required for plateletpheresis donors. Furthermore, these data indicate that the FDA could eliminate the requirement for the warning in informed consents about lymphocyte depletion in platelet donors.

AB - Previous studies of changes in immune function in platelet donors have investigated subjects who were undergoing plateletpheresis using older equipment that is no longer in general use. Therefore, the purpose of this study was to determine the effect of long-term platelet donation on lymphocyte numbers and subsets and plasma protein concentrations in platelet donors using newer cell separators. Three groups included in the study were nondonor controls (n=27), long-term whole blood donors (n=29), and long-term platelet donors (n=20). Using a cross-sectional analysis, lymphocyte numbers and subsets were determined and compared among the three groups. Plasma concentrations of total protein, globulin, albumin, and IgG were also compared. Among the three groups there were no significant differences in total white blood cell counts, percentage or absolute number of lymphocytes, or percentage or absolute number of lymphocyte subsets. Serum total protein, globulin, albumin, and IgG concentrations of platelet donors were within normal ranges. These data support the current Food and Drug Administration (FDA) and American Association of Blood Banks' standards for the frequency of platelet donation allowed and monitoring required for plateletpheresis donors. Furthermore, these data indicate that the FDA could eliminate the requirement for the warning in informed consents about lymphocyte depletion in platelet donors.

UR - http://www.scopus.com/inward/record.url?scp=0346676910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346676910&partnerID=8YFLogxK

M3 - Article

VL - 18

SP - 205

EP - 213

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

SN - 1473-0502

IS - 2

ER -