Effect of long-term bromocriptine infusion on plasma prolactin and ovine chorionic somatomammotropin in the pregnant ewe and fetal sheep

Kenneth C. Lowe, Neil F.G. Beck, Denise C. McNaughton, Peter D. Gluckman, Selna L. Kaplan, Melvin M. Grumbach, Peter W. Nathanielsz

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

It has been shown in previous studies that the continuous infusion of bromocriptine (CB 154) into either the sheep fetus or pregnant ewe was followed by pronounced ultrastructural changes in the binucleate (BN) cells of the ovine chorionic epithelium, which are a likely source of ovine chorionic somatomammotropin (oCS). We have examined ovine fetal and maternal plasma prolactin (PRL) and oCS concentrations following intravascular CB 154 infusion separately into either the fetus (0.03 mg/hour) or ewe (0.2 mg/hour). The CB 154 infusions significantly depressed fetal and maternal plasma radioimmunoassayable PRL concentrations within 24 hours of the commencement of infusion. Maternal plasma radioimmunoassayable oCS concentration was significantly depressed during infusion of CB 154 to the ewe, but the infusion of CB 154 to the fetus did not lower fetal plasma radioimmunoassayable oCS concentration or affect the duration of gestation.

Original languageEnglish (US)
Pages (from-to)773-777
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume135
Issue number6
DOIs
StatePublished - Nov 15 1979
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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