Effect of isoproterenol and dibutyryl cyclic AMP on thyroxine type-II 5′-deiodinase and N-acetyltransferase activities in rat pineal organ cultures

J. M. Guerrero, C. Santana, R. J. Reiter

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26 Scopus citations

Abstract

The effects of either isoproterenol or dibutyryl cyclic AMP on rat pineal thyroxine type-II 5′-deiodinase (5′-D) and N-acetyltransferase (NAT) activities were studied using an organ culture technique. Moving the animals to light at night dramatically inhibited the NAT with no change in the 5′-D activity. The subsequent incubation of pineal glands with either isoproterenol or dibutyryl cyclic AMP restored the NAT activity and caused a further rise in 5′-D activity. In animals maintained under light conditions during the night, both isoproterenol and dibutyryl cyclic AMP were able to stimulate the 5′-D and NAT activities. The results suggest that the β-adrenergic activation of the 5′-D activity is mediated by cyclic AMP in the rat pineal gland.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalNeuroscience Letters
Volume89
Issue number2
DOIs
StatePublished - Jun 29 1988

Keywords

  • Dibutyryl cyclic adenosine monophosphate
  • Isoproterenol
  • N-Acetyltransferase
  • Rat pineal gland
  • Thyroxine type-II 5′-deiodinase

ASJC Scopus subject areas

  • Neuroscience(all)

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