Effect of intravenous dose on hydralazine kinetics after administration

T. M. Ludden, A. M.M. Shepherd, J. L. McNay, M. Lin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Six male hypertensive patients, three rapid and three slow acetylators, each received four different intravenous hydralazine doses by constant infusion over 100 sec. Two to four days elapsed between doses. Plasma or whole-blood hydralazine concentrations were measured by HPLC after each dose. There was no influence of acetylator phenotype on hydralazine kinetics after intravenous dosing. There also was no consistent effect of dose size on hydralazine clearance or volume of distribution at doses up to 0.45 mg (2.3 μmol/kg). One subject, who received doses up to 0.6 mglkg (3.05 μmol), had an apparent decrease in clearance at the higher doses. These findings are consistent with the fact that hydralazine is converted intravascularly to hydralazine pyruvic acid hydrazone and the fact that potentially saturable hepatic metabolic pathways play only a modest role in systemic clearance.

Original languageEnglish (US)
Pages (from-to)148-152
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume34
Issue number2
DOIs
StatePublished - Aug 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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