Effect of interferon-α on cognitive functioning in patients with chronic hepatitis C

Robin C. Hilsabeck, Tarek I. Hassanein, Elizabeth A. Ziegler, Meghan D. Carlson, William Perry

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Treatment with interferon-alpha (IFN-α) has been shown to adversely affect cognitive functioning in patients with a variety of medical disorders, but information about the effects of IFN-α on cognitive functioning in patients with chronic hepatitis C (CHC) is limited. The purpose of this study was to examine the effects of IFN-α on neuropsychological test performance in CHC patients. Participants were 30 patients with CHC, 11 who underwent IFN-α therapy and 19 who did not. All participants were tested at baseline (i.e., pretreatment) and approximately 6 months later with the Symbol Digit Modalities Test and Trail Making Test. Results revealed that the treatment group performed significantly worse than untreated CHC patients on Part B of the Trail Making Test after approximately 6 months of treatment. No significant group differences were found on Part A of the Trail Making Test or Symbol Digit Modalities Test. Findings suggest that CHC patients undergoing treatment with IFN-α may experience reduced abilities to benefit from practice but suffer no decrements in performance after 6 months of treatment. Additional research is needed to replicate these findings and to explore risk factors for susceptibility to IFN-α-induced effects.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalJournal of the International Neuropsychological Society
Volume11
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Interferon-alpha
Interferons
Trail Making Test
Therapeutics
Aptitude
Neuropsychological Tests
Research

Keywords

  • Chronic liver disease
  • HCV
  • Neuropsychological impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Effect of interferon-α on cognitive functioning in patients with chronic hepatitis C. / Hilsabeck, Robin C.; Hassanein, Tarek I.; Ziegler, Elizabeth A.; Carlson, Meghan D.; Perry, William.

In: Journal of the International Neuropsychological Society, Vol. 11, No. 1, 01.2005, p. 16-22.

Research output: Contribution to journalArticle

Hilsabeck, Robin C. ; Hassanein, Tarek I. ; Ziegler, Elizabeth A. ; Carlson, Meghan D. ; Perry, William. / Effect of interferon-α on cognitive functioning in patients with chronic hepatitis C. In: Journal of the International Neuropsychological Society. 2005 ; Vol. 11, No. 1. pp. 16-22.
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