Effect of insulin on renal potassium metabolism

L. Rossetti, G. Klein-Robbenhaar, G. Giebisch, D. Smith, Ralph A Defronzo

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Citations (Scopus)

Abstract

The effect of insulin on renal potassium excretion was examined by employing the euglycemic insulin clamp technique in combination with renal clearance measurements. While euglycemia was maintained, insulin was infused at rates of 4.8 (n = 7) and 12 (n = 5) mU·kg-1·min-1. Steady-state plasma insulin levels of 164 ± 8 and 370 ± 15 μU/ml were achieved in the low- and high-dose studies, respectively. Base-line plasma potassium concentration declined progressively by a mean of 0.14 ± 0.09 (P < 0.05) and 0.40 ± 0.05 meq/liter (P < 0.01) during the low- and high-dose insulin infusion protocols. Urinary potassium excretion did not change significantly from base line with either insulin dose. Because the decline in plasma potassium concentration could have masked a stimulatory effect of insulin on U(K)V, six rats received a 12-mU·kg-1·min-1 euglycemic insulin clamp in combination with an exogenous potassium infusion to maintain the plasma potassium concentration constant at the basal level (4.03 ± 0.03 vs. 4.05 ± 0.05 meq/l). Under these conditions of normokalemia, insulin augmented U(K)V 2.4-fold, from 0.20 ± 0.05 to 0.48 ± 0.04 meq/l (P < 0.001).

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume252
Edition1
StatePublished - 1987
Externally publishedYes

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Potassium
Insulin
Kidney
Glucose Clamp Technique

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rossetti, L., Klein-Robbenhaar, G., Giebisch, G., Smith, D., & Defronzo, R. A. (1987). Effect of insulin on renal potassium metabolism. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology (1 ed., Vol. 252)

Effect of insulin on renal potassium metabolism. / Rossetti, L.; Klein-Robbenhaar, G.; Giebisch, G.; Smith, D.; Defronzo, Ralph A.

American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 252 1. ed. 1987.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rossetti, L, Klein-Robbenhaar, G, Giebisch, G, Smith, D & Defronzo, RA 1987, Effect of insulin on renal potassium metabolism. in American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1 edn, vol. 252.
Rossetti L, Klein-Robbenhaar G, Giebisch G, Smith D, Defronzo RA. Effect of insulin on renal potassium metabolism. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1 ed. Vol. 252. 1987
Rossetti, L. ; Klein-Robbenhaar, G. ; Giebisch, G. ; Smith, D. ; Defronzo, Ralph A. / Effect of insulin on renal potassium metabolism. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 252 1. ed. 1987.
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