Effect of injury on pulpal levels of immunoreactive substance P and immunoreactive calcitonin gene-related peptide

Eric H. Grutzner, Mary G. Garry, Kenneth M. Hargreaves

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P are present in dental pulp in relatively high concentrations. Previous studies have demonstrated that the staining density of immunoreactive CGRP (iCGRP) changes in dental pulp after tissue injury. This study evaluated injury-related changes in levels of both immunoreactive CGRP (iCGRP) and immunoreactive substance P (iSP) in dental pulp using radioimmunoassays. After pulpal exposure, iSP levels decreased to about 10% of baseline values, while iCGRP levels decreased to about 45% of baseline measures. After dentin exposure with acid etch, iSP levels decreased to about 10 to 20% of baseline measures, while iCGRP levels decreased to 60% of baseline values. For both forms of injury, iSP decreased to a greater extent than did iCGRP levels. Collectively, these findings indicate that pulpal neuropeptides undergo dynamic, injury-specific, and peptide-specific responses following trauma to dental pulp.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalJournal of endodontics
Volume18
Issue number11
DOIs
StatePublished - Nov 1992
Externally publishedYes

ASJC Scopus subject areas

  • Dentistry(all)

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