Effect of host fatty acid-binding protein and fatty acid uptake on growth of Chlamydia trachomatis L2

Guqi Wang, Frank Burczynski, Judy Anderson, Guangming Zhong

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Chlamydia trachomatis is an obligate intracellular bacterium and acquires both building blocks and energy from host cells for growth. The fatty acid-binding protein (FABP) plays an important role in uptake of long-chain fatty acids (LCFA) and energy metabolism by eukaryotic cells. The roles of FABIP and LCFA in chlamyclial infection were evaluated. Infection of liver cells with chlamydial organisms promoted fatty acid uptake by the infected cells, suggesting that LCFA may benefit chlamydial growth. Introduction of FABP into the liver cells not only enhanced fatty acid uptake, but also increased chlamydial intravacuolar replication and maturation. The FABP-enhanced chlamydial intracellular growth was dependent on the host cell uptake of fatty acids. These results have demonstrated that C. trachomatis can productively infect liver cells and utilize FABIP-transported LCFA for its own biosynthesis.

Original languageEnglish (US)
Pages (from-to)1935-1939
Number of pages5
JournalMicrobiology
Volume153
Issue number6
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Microbiology

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