Abstract
Introduction: Posttransplant diabetes mellitus (PTDM) can increase morbidity and mortality in liver transplant recipients. Although hepatitis C seropositivity is a known risk factor for PTDM, the impact of viremia versus no viremia at time of transplant is unknown. Project Aims: This program evaluation sought to compare PTDM in hepatitis C seropositive patients with and without viremia at the time of liver transplant. Design: This single-center retrospective review included adult hepatitis C seropositive liver transplant recipients transplanted between January 1, 2010 to September 5, 2017 without pretransplant diabetes. Primary outcome was PTDM within 1 year. Secondary outcomes included evaluating 1-year posttransplant death-censored graft loss, mortality, and metabolic outcomes. Results: Fifty-seven liver transplant recipients with hepatitis C were included, of which 53% (n = 30) were viremic at transplant. Baseline characteristics were similar between groups. Significantly more patients with pretransplant viremia developed PTDM by 1-year posttransplant compared to the patients without viremia (43% vs 11%, P = 0.01). There were no differences between groups outside of more patients with viremia requiring antihypertensives by 1-year posttransplant compared to patients without viremia (57% vs 22%, P = 0.01). Conclusion: Liver transplant patients with hepatitis C viremia at transplant were more likely to develop PTDM at 1 year compared to those without pretransplant viremia. This is an added consideration when deciding the timing of direct-acting antiviral (DAA) utilization in the context of liver transplant for hepatitis C seropositive patients.
Original language | English (US) |
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Pages (from-to) | 73-77 |
Number of pages | 5 |
Journal | Progress in Transplantation |
Volume | 32 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2022 |
Keywords
- C
- clinical outcomes
- clinical outcomes
- clinical outcomes
- diabetes
- endocrinology
- general
- hepatitis B
- immunology
- infection
- liver transplantation
- posttransplant
- type 2
ASJC Scopus subject areas
- Transplantation