Effect of Hepatitis C Viremia on Posttransplant Diabetes Mellitus in Liver Transplant Recipients

Kelsey Klein, Joelle Nelson, Christina Long, Kermit Speeg, Naim Alkhouri, Reed Hall

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Posttransplant diabetes mellitus (PTDM) can increase morbidity and mortality in liver transplant recipients. Although hepatitis C seropositivity is a known risk factor for PTDM, the impact of viremia versus no viremia at time of transplant is unknown. Project Aims: This program evaluation sought to compare PTDM in hepatitis C seropositive patients with and without viremia at the time of liver transplant. Design: This single-center retrospective review included adult hepatitis C seropositive liver transplant recipients transplanted between January 1, 2010 to September 5, 2017 without pretransplant diabetes. Primary outcome was PTDM within 1 year. Secondary outcomes included evaluating 1-year posttransplant death-censored graft loss, mortality, and metabolic outcomes. Results: Fifty-seven liver transplant recipients with hepatitis C were included, of which 53% (n = 30) were viremic at transplant. Baseline characteristics were similar between groups. Significantly more patients with pretransplant viremia developed PTDM by 1-year posttransplant compared to the patients without viremia (43% vs 11%, P = 0.01). There were no differences between groups outside of more patients with viremia requiring antihypertensives by 1-year posttransplant compared to patients without viremia (57% vs 22%, P = 0.01). Conclusion: Liver transplant patients with hepatitis C viremia at transplant were more likely to develop PTDM at 1 year compared to those without pretransplant viremia. This is an added consideration when deciding the timing of direct-acting antiviral (DAA) utilization in the context of liver transplant for hepatitis C seropositive patients.

Original languageEnglish (US)
JournalProgress in Transplantation
DOIs
StateAccepted/In press - 2021

Keywords

  • C
  • clinical outcomes
  • clinical outcomes
  • clinical outcomes
  • diabetes
  • endocrinology
  • general
  • hepatitis B
  • immunology
  • infection
  • liver transplantation
  • posttransplant
  • type 2

ASJC Scopus subject areas

  • Transplantation

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