Effect of gender mismatch on survival in lung transplant patients

Irawan Susanto, S. M. Levine, J. I. Peters, A. Anzueto, E. Y. Sako, S. G. Jenkinson, C. L. Bryan

Research output: Contribution to journalArticle

Abstract

Purpose: Gender mismatch has recently been associated with decreased survival in heart transplantation when a female donor heart was transplanted to a male recipient. (J Heart Lung Transplant 1996;15(1):33A). The effect of gender mismatch in lung transplantation is not clear. This study investigated the impact of gender mismatch on lung transplant survival at a single institution. Methods: We retrospectively reviewed the survival data of lung transplantation gender match and mismatch at our institution between 1987 and 1995. Patients were divided into four groups of donor-recipient (D-R) pairs: male to male (MM), male to female (MF), female to female (FF), and female to male (FM). Results: There were significantly fewer female donors compared to male donors (M:F ratio 4.7:1). No significant differences were found among the four groups in recipient diagnosis, total ischemic time and length of hospital stay. The following table shows the survival data: Percent Survival D-R 1 Year 2 Year 3 Year MM 62 (28/45) 53 (20/38) 38 (13/34) MF 56 (22/39) 46 (17/37) 42 (13/31) FF 92 (12/13) 67 (8/12) 44 (4/9) FM 60 (3/5) 40 (2/5) 33 (1/3) Total 64 51 40 Conclusions: Gender match from female donor to female recipient appears to have the highest survival rates. Gender mismatch from female donor to male recipient appears to have slightly lower two-year and three-year survival rates compared to gender matched pairs. However, given the few number of patients in this group, the clinical significance of this finding is unclear. Clinical Implications: Given the current shortage of organ donors, the small differences in survival rates in gender mismatch do not favor gender matching in lung transplantation.

Original languageEnglish (US)
Pages (from-to)222S
JournalChest
Volume110
Issue number4 SUPPL.
StatePublished - Oct 1 1996

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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