Effect of gamma interferon on resolution of murine chlamydial genital infection

R. G. Rank; K. H. Ramsey; E. A. Pack; D. M. Williams

Effect of gamma interferon on resolution of murine chlamydial genital infection

R. G. Rank, K. H. Ramsey, E. A. Pack, D. M. Williams

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-γ) antibody to determine whether IFN-γ participated in the resolution of the infection. In two experiments, anti-IFN-γ antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-γ to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.

Original language	English (US)
Pages (from-to)	4427-4429
Number of pages	3
Journal	Infection and immunity
Volume	60
Issue number	10
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

Cite this

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title = "Effect of gamma interferon on resolution of murine chlamydial genital infection",

abstract = "Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-γ) antibody to determine whether IFN-γ participated in the resolution of the infection. In two experiments, anti-IFN-γ antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-γ to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.",

author = "Rank, {R. G.} and Ramsey, {K. H.} and Pack, {E. A.} and Williams, {D. M.}",

year = "1992",

language = "English (US)",

volume = "60",

pages = "4427--4429",

journal = "Infection and Immunity",

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publisher = "American Society for Microbiology",

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AU - Rank, R. G.

AU - Ramsey, K. H.

AU - Pack, E. A.

AU - Williams, D. M.

PY - 1992

Y1 - 1992

N2 - Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-γ) antibody to determine whether IFN-γ participated in the resolution of the infection. In two experiments, anti-IFN-γ antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-γ to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.

AB - Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-γ) antibody to determine whether IFN-γ participated in the resolution of the infection. In two experiments, anti-IFN-γ antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-γ to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.

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M3 - Comment/debate

C2 - 1398955

AN - SCOPUS:0026660316

SN - 0019-9567

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JO - Infection and Immunity

JF - Infection and Immunity

IS - 10

ER -

Effect of gamma interferon on resolution of murine chlamydial genital infection

Abstract

ASJC Scopus subject areas

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