Effect of food withdrawal on arterial blood glucose and plasma 13,14-dihydro-15-keto-prostaglandin F concentrations and nocturnal myometrial electromyographic activity in the pregnant rhesus monkey in the last third of gestation: A model for preterm labor?

Z. Binienda, A. Massmann, M. D. Mitchell, R. D. Gleed, J. P. Figueroa, P. W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Pregnant rhesus monkeys were studied between 109 and 149 days of gestation. Food withdrawal for 48 hours (with free access to water) was accompanied by a decrease in maternal whole blood glucose concentration and an increased maternal arterial plasma 13,14-dihydro-15-keto-prostag land in F concentration. On successive nights of the 48-hour period of food withdrawal, there was an increase in the frequency of myometrial contractions as recorded by uterine electromyogram. In the period after food was returned, blood glucose, arterial 13,14-dihydro-15-keto-prostaglandin F concentration, and contraction frequency returned to baseline. Because food withdrawal results in the appearance of the nocturnal contraction pattern seen at term, we suggest that this experimental paradigm may be used as a model for preterm labor.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume160
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Preterm labor
  • maternal nutrition
  • myometrial activity

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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