Effect of fetal intravascular 4-aminoantipyrine infusions on myometrial activity (contractures) at 125 to 143 days' gestation in the pregnant sheep

Adel El Badry, J. P. Figueroa, E. R. Poore, S. Sunderji, S. Levine, M. D. Mitchell, P. W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Myometrial activity of low amplitude and long duration—contractures—is present throughout gestation in the pregnant ewe and other species. This activity differs from the contractions of labor and delivery. Between 125 and 143 days' gestation, 4-aminoantipyrine infused into the fetus at rates that produced maternal uterine vein plasma concentrations of 4-aminoantipyrine of 5.95 ± 1.23 (mean ± SEM, n = 5) mg - 100 ml-' markedly depressed both total myometrial electromyographic activity to 28.6% and frequency of contractures to 30.5% of preinfusion values. By 60 minutes of infusion, maternal uterine vein plasma 13,14-dihydro-15-keto prostaglandin F concentration was reduced to 14% of the resting level. Two conclusions were drawn from this study. First, prostaglandins are involved in the regulation of contractures. Second, when infusions of 4-aminoantipyrine are used to quantify uterine or umbilical blood flow, the possibility exists that changes will occur in physiologic systems that are modified by prostaglandins.

Original languageEnglish (US)
Pages (from-to)474-479
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume150
Issue number5
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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