Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats

Takeyoshi Ohkura, J. W. Lee, N. Hagino

Research output: Contribution to journalArticlepeer-review

Abstract

Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1-10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalInternational Journal of Developmental Neuroscience
Volume4
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Dopamine
  • Hypothalamus
  • Neonatal brain
  • Norepinephrine

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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