TY - JOUR
T1 - Effect of exercise training on peak oxygen consumption in patients with cancer
T2 - A meta-analysis
AU - Jones, Lee W.
AU - Liang, Yuanyuan
AU - Pituskin, Edith N.
AU - Battaglini, Claudio L.
AU - Scott, Jessica M.
AU - Hornsby, Whitney E.
AU - Haykowsky, Mark
PY - 2011
Y1 - 2011
N2 - Background. We conducted a meta-analysis to determine the effects of supervised exercise training on peak oxygen consumption (VO2peak) in adults with cancer. Methods. A literature review using Ovid MEDLINE (1950-2010), the Cochrane Central Register of Controlled Trials (1991-2010), AMED (1985-2010), Embase (1988-2010), PubMed (1966-2010), Scopus (1950-2010), and Web of Science (1950-2010) was performed to identify randomized controlled trials examining the effects of supervised exercise training on measurement of VO2peak (via gas exchange analysis) in adults with cancer. Studies were selected using predetermined criteria, and two independent reviewers extracted data. Weighted mean differences (WMDs) were calculated using random effect models. Results. Six studies evaluated VO2peak involving a total of 571 adult cancer patients (exercise, n-344; usual care control, n- 227). Pooled data indicated that exercise training was associated with a statistically significant increase in VO2peak (WMD, 2.90 ml·kg-1·min-1; 95% confidence interval [CI], 1.16-4.64); however, significant heterogeneity was evident in this estimate (I2, 87%). Usual care (control) was associated with a significant decline in VO2peak from baseline to post intervention (WMD,-1.02 ml·kg-1·min-1; 95% CI,-1.46 to-0.58; I2, 22%). Sensitivity analyses indicated superior improvements in VO2peak for studies conducted for a shorter duration (<4 months) and following the completion of adjuvant therapy (p-values <.001). Exercise training was not associated with a higher incidence of adverse events, although safety was not rigorously monitored or reported. Conclusions. Supervised exercise training is associated with significant improvements in VO2peak following a diagnosis of early-stage cancer, with minimal adverse events.
AB - Background. We conducted a meta-analysis to determine the effects of supervised exercise training on peak oxygen consumption (VO2peak) in adults with cancer. Methods. A literature review using Ovid MEDLINE (1950-2010), the Cochrane Central Register of Controlled Trials (1991-2010), AMED (1985-2010), Embase (1988-2010), PubMed (1966-2010), Scopus (1950-2010), and Web of Science (1950-2010) was performed to identify randomized controlled trials examining the effects of supervised exercise training on measurement of VO2peak (via gas exchange analysis) in adults with cancer. Studies were selected using predetermined criteria, and two independent reviewers extracted data. Weighted mean differences (WMDs) were calculated using random effect models. Results. Six studies evaluated VO2peak involving a total of 571 adult cancer patients (exercise, n-344; usual care control, n- 227). Pooled data indicated that exercise training was associated with a statistically significant increase in VO2peak (WMD, 2.90 ml·kg-1·min-1; 95% confidence interval [CI], 1.16-4.64); however, significant heterogeneity was evident in this estimate (I2, 87%). Usual care (control) was associated with a significant decline in VO2peak from baseline to post intervention (WMD,-1.02 ml·kg-1·min-1; 95% CI,-1.46 to-0.58; I2, 22%). Sensitivity analyses indicated superior improvements in VO2peak for studies conducted for a shorter duration (<4 months) and following the completion of adjuvant therapy (p-values <.001). Exercise training was not associated with a higher incidence of adverse events, although safety was not rigorously monitored or reported. Conclusions. Supervised exercise training is associated with significant improvements in VO2peak following a diagnosis of early-stage cancer, with minimal adverse events.
KW - Aerobic capacity
KW - Aerobic training
KW - Peak oxygen consumption
KW - Randomized controlled trials
KW - Resistance training
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U2 - 10.1634/theoncologist.2010-0197
DO - 10.1634/theoncologist.2010-0197
M3 - Article
C2 - 21212429
AN - SCOPUS:79952589266
VL - 16
SP - 112
EP - 120
JO - Oncologist
JF - Oncologist
SN - 1083-7159
IS - 1
ER -