Abstract
Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14. Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1569-1574 |
| Number of pages | 6 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 172 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 15 2005 |
| Externally published | Yes |
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Keywords
- Bronchopulmonary dysplasia
- Chronic lung disease
- Patent ductus arteriosus
- Premature newborn
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Effect of ductus ligation on cardiopulmonary function in premature baboons. / Mccurnin, Donald C; Yoder, Bradley A.; Coalson, Jacqueline; Grubb, Peter; Kerecman, Jay; Kupferschmid, John; Breuer, Chris; Siler-Khodr, Theresa; Shaul, Philip W.; Clyman, Ronald.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 172, No. 12, 15.12.2005, p. 1569-1574.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of ductus ligation on cardiopulmonary function in premature baboons
AU - Mccurnin, Donald C
AU - Yoder, Bradley A.
AU - Coalson, Jacqueline
AU - Grubb, Peter
AU - Kerecman, Jay
AU - Kupferschmid, John
AU - Breuer, Chris
AU - Siler-Khodr, Theresa
AU - Shaul, Philip W.
AU - Clyman, Ronald
PY - 2005/12/15
Y1 - 2005/12/15
N2 - Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14. Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.
AB - Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14. Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.
KW - Bronchopulmonary dysplasia
KW - Chronic lung disease
KW - Patent ductus arteriosus
KW - Premature newborn
UR - http://www.scopus.com/inward/record.url?scp=30444436754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30444436754&partnerID=8YFLogxK
U2 - 10.1164/rccm.200502-230OC
DO - 10.1164/rccm.200502-230OC
M3 - Article
C2 - 16179644
AN - SCOPUS:30444436754
VL - 172
SP - 1569
EP - 1574
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 12
ER -