Effect of ductus ligation on cardiopulmonary function in premature baboons

Donald C Mccurnin, Bradley A. Yoder, Jacqueline Coalson, Peter Grubb, Jay Kerecman, John Kupferschmid, Chris Breuer, Theresa Siler-Khodr, Philip W. Shaul, Ronald Clyman

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14. Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.

Original languageEnglish (US)
Pages (from-to)1569-1574
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume172
Issue number12
DOIs
StatePublished - Dec 15 2005
Externally publishedYes

Fingerprint

Papio
Ligation
Patent Ductus Arteriosus
Surface-Active Agents
Lung
Lung Compliance
Respiratory Function Tests
Lung Injury
Interleukin-8
Primates
Lung Diseases
Compliance
Ventilation
Interleukin-6
Histology
Chronic Disease
Cytokines
Hypertension

Keywords

  • Bronchopulmonary dysplasia
  • Chronic lung disease
  • Patent ductus arteriosus
  • Premature newborn

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mccurnin, D. C., Yoder, B. A., Coalson, J., Grubb, P., Kerecman, J., Kupferschmid, J., ... Clyman, R. (2005). Effect of ductus ligation on cardiopulmonary function in premature baboons. American Journal of Respiratory and Critical Care Medicine, 172(12), 1569-1574. https://doi.org/10.1164/rccm.200502-230OC

Effect of ductus ligation on cardiopulmonary function in premature baboons. / Mccurnin, Donald C; Yoder, Bradley A.; Coalson, Jacqueline; Grubb, Peter; Kerecman, Jay; Kupferschmid, John; Breuer, Chris; Siler-Khodr, Theresa; Shaul, Philip W.; Clyman, Ronald.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 172, No. 12, 15.12.2005, p. 1569-1574.

Research output: Contribution to journalArticle

Mccurnin, DC, Yoder, BA, Coalson, J, Grubb, P, Kerecman, J, Kupferschmid, J, Breuer, C, Siler-Khodr, T, Shaul, PW & Clyman, R 2005, 'Effect of ductus ligation on cardiopulmonary function in premature baboons', American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 12, pp. 1569-1574. https://doi.org/10.1164/rccm.200502-230OC
Mccurnin, Donald C ; Yoder, Bradley A. ; Coalson, Jacqueline ; Grubb, Peter ; Kerecman, Jay ; Kupferschmid, John ; Breuer, Chris ; Siler-Khodr, Theresa ; Shaul, Philip W. ; Clyman, Ronald. / Effect of ductus ligation on cardiopulmonary function in premature baboons. In: American Journal of Respiratory and Critical Care Medicine. 2005 ; Vol. 172, No. 12. pp. 1569-1574.
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