Abstract
1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | General Pharmacology |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1975 |
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Keywords
- dopamine-β-hydroxylase
- drug effects
- Parathyroid glands
- pineal gland
- rat
- seizures
- tryptophan hydroxylase
ASJC Scopus subject areas
- Pharmacology
Cite this
Effect of drugs which inhibit tryptophan hydroxylase or dopamine-β-hydroxylase on pinealectomy-induced seizures in parathyroidectomized rats. / Reiter, Russel J; Johnson, Linda Y; Bigelow, Lewellyn.
In: General Pharmacology, Vol. 6, No. 1, 1975, p. 53-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of drugs which inhibit tryptophan hydroxylase or dopamine-β-hydroxylase on pinealectomy-induced seizures in parathyroidectomized rats
AU - Reiter, Russel J
AU - Johnson, Linda Y
AU - Bigelow, Lewellyn
PY - 1975
Y1 - 1975
N2 - 1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.
AB - 1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.
KW - dopamine-β-hydroxylase
KW - drug effects
KW - Parathyroid glands
KW - pineal gland
KW - rat
KW - seizures
KW - tryptophan hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=49549144453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49549144453&partnerID=8YFLogxK
U2 - 10.1016/0306-3623(75)90012-9
DO - 10.1016/0306-3623(75)90012-9
M3 - Article
VL - 6
SP - 53
EP - 57
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 1
ER -