Effect of drugs which inhibit tryptophan hydroxylase or dopamine-β-hydroxylase on pinealectomy-induced seizures in parathyroidectomized rats

Russel J Reiter, Linda Y Johnson, Lewellyn Bigelow

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalGeneral Pharmacology
Volume6
Issue number1
DOIs
StatePublished - 1975

Fingerprint

Tryptophan Hydroxylase
Mixed Function Oxygenases
Dopamine
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide
Seizures
Pharmaceutical Preparations
Melatonin
Norepinephrine
Injections
Brain

Keywords

  • dopamine-β-hydroxylase
  • drug effects
  • Parathyroid glands
  • pineal gland
  • rat
  • seizures
  • tryptophan hydroxylase

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Effect of drugs which inhibit tryptophan hydroxylase or dopamine-β-hydroxylase on pinealectomy-induced seizures in parathyroidectomized rats",
abstract = "1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.",
keywords = "dopamine-β-hydroxylase, drug effects, Parathyroid glands, pineal gland, rat, seizures, tryptophan hydroxylase",
author = "Reiter, {Russel J} and Johnson, {Linda Y} and Lewellyn Bigelow",
year = "1975",
doi = "10.1016/0306-3623(75)90012-9",
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pages = "53--57",
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T1 - Effect of drugs which inhibit tryptophan hydroxylase or dopamine-β-hydroxylase on pinealectomy-induced seizures in parathyroidectomized rats

AU - Reiter, Russel J

AU - Johnson, Linda Y

AU - Bigelow, Lewellyn

PY - 1975

Y1 - 1975

N2 - 1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.

AB - 1. 1. If 21 day-old male rats are parathyroidectomized (PTX) and a week later are pinealectomized (PX) about 80 per cent of the animals exhibit repeated seizures during the first 8 hr following PX. Within 48 hr roughly 35 per cent of these animals die. 2. 2. The administration of FLA-63, a dopamine-β-hydroxylase inhibitor, 60 min after PX caused a rapid onset of the seizures in all the animals. Additionally, 100 per cent of the rats given FLA-63 were dead within 3 hr of PX. 3. 3. The injection of p-CPA, a tryptophan hydroxylase inhibitor, at 48 and 24 hr preceding PX, only slightly increased the frequency of the seizures. 4. 4. The administration of a melatonin-free pineal extract had no influence on the convulsive episodes in PTX + PX rats. 5. 5. In support of previously obtained biochemical data, the results suggested that depressed brain norepinephrine may somehow be related to the seizures in PTX + PX rats.

KW - dopamine-β-hydroxylase

KW - drug effects

KW - Parathyroid glands

KW - pineal gland

KW - rat

KW - seizures

KW - tryptophan hydroxylase

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