TY - JOUR
T1 - Effect of dietary restriction on DNA repair and DNA damage
AU - Haley-Zitlin, Vivian
AU - Richardson, Arlan
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993/12
Y1 - 1993/12
N2 - Dietary restriction is the only experimental manipulation known to extend lifespan and retard aging in mammals. Therefore, it is a powerful tool for identifying cellular processes that are involved in aging and senescence. Recently, several laboratories have begun to examine the effects of dietary restriction on the integrity of the genome and the ability of cells to repair DNA. In most studies, it was found that the repair of DNA damage, as measured by unscheduled DNA synthesis, was significantly higher in cells isolated from rodents fed calorie-restricted diets compared to cells isolated from rodents fed ad libitum. Dietary restriction also was observed to be associated with a reduction of the levels of certain types of DNA damage; however, preliminary experiments suggest that the effect of dietary restriction on the age-related accumulation of DNA damage depends on the type of DNA damage studied.
AB - Dietary restriction is the only experimental manipulation known to extend lifespan and retard aging in mammals. Therefore, it is a powerful tool for identifying cellular processes that are involved in aging and senescence. Recently, several laboratories have begun to examine the effects of dietary restriction on the integrity of the genome and the ability of cells to repair DNA. In most studies, it was found that the repair of DNA damage, as measured by unscheduled DNA synthesis, was significantly higher in cells isolated from rodents fed calorie-restricted diets compared to cells isolated from rodents fed ad libitum. Dietary restriction also was observed to be associated with a reduction of the levels of certain types of DNA damage; however, preliminary experiments suggest that the effect of dietary restriction on the age-related accumulation of DNA damage depends on the type of DNA damage studied.
KW - DNA damage
KW - DNA repair
KW - Dietary restriction
UR - http://www.scopus.com/inward/record.url?scp=0027723251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027723251&partnerID=8YFLogxK
U2 - 10.1016/0921-8734(93)90023-V
DO - 10.1016/0921-8734(93)90023-V
M3 - Article
C2 - 7507560
AN - SCOPUS:0027723251
VL - 295
SP - 237
EP - 245
JO - Mutation Research DNAging
JF - Mutation Research DNAging
SN - 0921-8734
IS - 4-6
ER -