Effect of diclofenac on plasma levels of immunoreactive prolactin, follicle stimulating hormone, luteinizing hormone, thyrotropin, and β-endorphin in humans

Jean Joris, A. M. Reuter, Y. Vrindts-Gevaert, R. Gathy-Meuleman, K. Hargreave, P. Franchi Mont

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Prostaglandins have been shown to modulate the secretion of several pituitary hormones, suggesting that therapeutic doses of nonsteroidal anti-inflammatory drugs may change basal hormone levels. In this study, plasma levels of prolactin, follicle stimulating hormone, luteinizing hormone, thyrotropinand beta-endorphin were determined in 6 healthy men after administration of diclofenac, a prostaglandin synthesis inhibitor. The subjects were given 75mg intramuscularly and 50 mg orally at 08.00 h the first day, 50 mg orally at 08.00, 12.00 and 20.00 h the second day and an additional 50 mg orally at 08.00 h the third day. Blood samples were collected throughout these 3 days. Diclofenac resulted in a significant and sustained decrease in plasma level of prolactin (p < 0.005). The other hormones did not demonstrate significant change following diclofenac administration.These data suggest that administration of a prostaglandin synthesis inhibitor, such as diclofenac, selectively alters basal pituitary secretion of prolactin in humans without a detectable effect on plasma levels of other pituitary hormones. This study supports the hypothesis that prostaglandins are necessary for maintainingbasal level of prolactin secretion in man.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalHormone Research in Paediatrics
Volume29
Issue number4
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Keywords

  • Adenohypophyseal hormones
  • Beta-endorphin
  • Diclofenac
  • FSH
  • LH
  • Nonsteroidal anti-inflammatory drugs
  • PRL
  • Prostaglandins
  • TSH

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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