Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon

N. Hagino; O. Nakamoto; Y. Kunz; A. Arimura; D. H. Coy; A. V. Schally

doi:10.1530/acta.0.0910217

Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon

N. Hagino, O. Nakamoto, Y. Kunz, A. Arimura, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An effect of D-Trp6-LH-RH (superactive LH-RH agonist) in the pituitary and ovarian function was examined. Four regularly cycling baboons were used for this study. After determination of control values of plasma levels of LH, oestrogen and progesterone during the entire menstrual cycle, D-Trp6-LH-RH was infused subcutaneously for 7 days during the early luteal phase in these four baboons. An infusion of D-Trp6-LH-RH increased plasma LH and oestrogen, but it failed to alter the plasma level of progesterone. From these results, it seems unlikely that D-Trp6-LH-RH has a luteolytic effect, and an increased ovarian oestrogen causes luteolysis in the baboon.

Original language	English (US)
Pages (from-to)	217-223
Number of pages	7
Journal	Unknown Journal
Volume	91
Issue number	2
DOIs	https://doi.org/10.1530/acta.0.0910217
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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title = "Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon",

abstract = "An effect of D-Trp6-LH-RH (superactive LH-RH agonist) in the pituitary and ovarian function was examined. Four regularly cycling baboons were used for this study. After determination of control values of plasma levels of LH, oestrogen and progesterone during the entire menstrual cycle, D-Trp6-LH-RH was infused subcutaneously for 7 days during the early luteal phase in these four baboons. An infusion of D-Trp6-LH-RH increased plasma LH and oestrogen, but it failed to alter the plasma level of progesterone. From these results, it seems unlikely that D-Trp6-LH-RH has a luteolytic effect, and an increased ovarian oestrogen causes luteolysis in the baboon.",

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T1 - Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon

AU - Hagino, N.

AU - Nakamoto, O.

AU - Kunz, Y.

AU - Arimura, A.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1979

Y1 - 1979

N2 - An effect of D-Trp6-LH-RH (superactive LH-RH agonist) in the pituitary and ovarian function was examined. Four regularly cycling baboons were used for this study. After determination of control values of plasma levels of LH, oestrogen and progesterone during the entire menstrual cycle, D-Trp6-LH-RH was infused subcutaneously for 7 days during the early luteal phase in these four baboons. An infusion of D-Trp6-LH-RH increased plasma LH and oestrogen, but it failed to alter the plasma level of progesterone. From these results, it seems unlikely that D-Trp6-LH-RH has a luteolytic effect, and an increased ovarian oestrogen causes luteolysis in the baboon.

AB - An effect of D-Trp6-LH-RH (superactive LH-RH agonist) in the pituitary and ovarian function was examined. Four regularly cycling baboons were used for this study. After determination of control values of plasma levels of LH, oestrogen and progesterone during the entire menstrual cycle, D-Trp6-LH-RH was infused subcutaneously for 7 days during the early luteal phase in these four baboons. An infusion of D-Trp6-LH-RH increased plasma LH and oestrogen, but it failed to alter the plasma level of progesterone. From these results, it seems unlikely that D-Trp6-LH-RH has a luteolytic effect, and an increased ovarian oestrogen causes luteolysis in the baboon.

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Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon

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