This study evaluated the effect of cimetidine, an H2-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.
ASJC Scopus subject areas