Effect of cimetidine on gastric secretory function during stress

Barry A. Levine; Kenneth R. Sirinek; David K. Teegarden; Charles G. McLoed; Basil A. Pruitt

doi:10.1016/0022-4804(78)90171-3

Effect of cimetidine on gastric secretory function during stress

Barry A. Levine, Kenneth R. Sirinek, David K. Teegarden, Charles G. McLoed, Basil A. Pruitt

Surgery

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6 Scopus citations

Abstract

This study evaluated the effect of cimetidine, an H₂-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.

Original language	English (US)
Pages (from-to)	178-181
Number of pages	4
Journal	Journal of Surgical Research
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0022-4804(78)90171-3
State	Published - Mar 1978

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Surgery

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Levine, B. A., Sirinek, K. R., Teegarden, D. K., McLoed, C. G., & Pruitt, B. A. (1978). Effect of cimetidine on gastric secretory function during stress. Journal of Surgical Research, 24(3), 178-181. https://doi.org/10.1016/0022-4804(78)90171-3

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abstract = "This study evaluated the effect of cimetidine, an H2-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.",

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AU - Pruitt, Basil A.

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10.1016/0022-4804(78)90171-3