Effect of Cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffein

P. V. Desmond, R. Patwardhan, R. Parker, S. Schenker, K. V. Speeg

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Cimetidine is widely prescribed for the treatment of peptic ulcer disease and has recently been shown to inhibit the metabolism of warfarin, antipyrine and diazepam. To further examine this phenomenon we investigated the effect of various doses of cimetidine and other related drugs on 14C-aminopyrine, 14C-phenacetin and 14C-caffeine breath tests. Cimetidine caused a dose-related inhibition of the metabolism of aminopyrine and caffeine but had no effect on the phenacetin breath test. Metiamide, H1-antihistamines, phenothiazines and local anesthetics also inhibited the aminopyrine breath test. Cyproheptadine had no effect on either phenacetin or caffeine elimination. This study demonstrates a complex drug-drug interaction which may have widespread clinical implications.

Original languageEnglish (US)
Pages (from-to)1261-1268
Number of pages8
JournalLife Sciences
Volume26
Issue number15
DOIs
StatePublished - Apr 14 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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