Effect of calorie restriction on the production and responsiveness to interleukin 2 in (NZB × NZW)F1 mice

Lawrence K.L. Jung, Michael A. Palladino, Steven Calvano, David A. Mark, Robert A. Good, Gabriel Fernandes

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Calorie restriction preserves the immunologic functions of the autoimmune prone B/W mice and prolongs their life. B/W mice fed normal calories were deficient in production of Interleukin 2 (IL-2) and in responses to exogenous IL-2 after 5 months of age. Calorie restriction leads to the preservation of IL-2 production in the spleen cells of these animals. Furthermore, these calorie-restricted mice responded vigorously to exogenous IL-2 in the thymocyte proliferation assay while mice fed a normal calorie diet lost much of the ability of their thymocytes to respond to IL-2. Whether calorie restriction in preserving the immune function of B/W mice involves IL-2 production and/or IL-2 response requires further analysis.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalClinical Immunology and Immunopathology
Volume25
Issue number2
DOIs
StatePublished - Nov 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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