Effect of brief vascular perfusion on the ultrastructure and activity of mitochondria isolated from the rat heart

J. L. Staecker, M. J. Nadakavukaren, A. Richardson

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Abstract

Mitochondria isolated from heart tissue after a 1-min perfusion with Hanks medium were found to have significantly lower rates of State-3 respiration and respiratory control ratios compared to mitochondria isolated from non-perfused hearts. Examination of the mitochondrial preparations by electron microscopy revealed that a large proportion of the mitochondria isolated from perfused heart tissue were swollen and broken compared to mitochondria from non-perfused hearts.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalCell and Tissue Research
Volume240
Issue number1
DOIs
Publication statusPublished - Apr 1 1985

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Keywords

  • Heart
  • Mitochondria
  • Perfusion
  • Rat
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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