Effect of bone remodeling coupling factors on osteogenic differentiation of human mesenchymal stem cells induced by microstructured titanium surfaces

Jingyao Deng, D. Joshua Cohen, Zvi Schwartz, Barbara D. Boyan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Osseointegration is a structural and functional contact between a load-bearing implant and living bone, which ensures the success of dental and orthopaedic implants. A critical stage in osseointegration is primary bone remodeling. It requires the balance in the coupling system between bone formation and bone resorption. Understanding the coupling mechanisms underlying bone remodeling and investigating the coupling factors involved will allow us to improve the osseointegration and develop better dental or orthopaedic implants. A new class of molecules has been recently reported to act as coupling factors in remodeling—the semaphorins. This project is focused on Sema4D, which has been reported to inhibit bone formation without affecting osteoclastogenesis during normal bone remodeling, as well as Sema3C, which has been less studies in the context of bone. Our lab previously found that Sema3C mRNA expression is upregulated in osteoblasts. Ti implants with rougher a n d / or hydrophilic surfaces can induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) or other osteoblast progenitor cells. Therefore, our goal was to determine the effect of semaphorins on osteogenic differentiation of hMSCs induced by microstructured Ti implant surfaces.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Deng, J., Cohen, D. J., Schwartz, Z., & Boyan, B. D. (2019). Effect of bone remodeling coupling factors on osteogenic differentiation of human mesenchymal stem cells induced by microstructured titanium surfaces. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.