Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats

A. Bhattacharya, M. Kumar, S. Ghosal, S. K. Bhattacharya

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered prophylactically (10, 20 and 50 mg/kg, p.o.) for 10 consecutive day, was found to inhibit acute iron overload (30 mg/kg, i.p.) hepatic lipid peroxidation and the increase of serum levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, used as markers of the induced hepatic dysfunction. A similar effect was produced by silymarin (20 mg/kg, p.o.), an antioxidant hepatoprotective agent. The results support the use of Emblica fruits for hepatoprotection in Ayurveda.

Original languageEnglish (US)
Pages (from-to)173-175
Number of pages3
JournalPhytomedicine
Volume7
Issue number2
StatePublished - Apr 2000
Externally publishedYes

Fingerprint

Phyllanthus emblica
hepatotoxicity
Fruits
Phyllanthus
Toxicity
Rats
Fruit
Iron
Antioxidants
iron
Silymarin
Iron Overload
fruits
Liver
rats
Aspartate Aminotransferases
Alanine Transaminase
L-Lactate Dehydrogenase
Lipid Peroxidation
Ayurvedic medicine

Keywords

  • Antioxidant action
  • Emblica officinalis
  • Emblicanin A and B
  • Iron-induced hepatotoxicity
  • Tannoids

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Bhattacharya, A., Kumar, M., Ghosal, S., & Bhattacharya, S. K. (2000). Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats. Phytomedicine, 7(2), 173-175.

Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats. / Bhattacharya, A.; Kumar, M.; Ghosal, S.; Bhattacharya, S. K.

In: Phytomedicine, Vol. 7, No. 2, 04.2000, p. 173-175.

Research output: Contribution to journalArticle

Bhattacharya, A, Kumar, M, Ghosal, S & Bhattacharya, SK 2000, 'Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats', Phytomedicine, vol. 7, no. 2, pp. 173-175.
Bhattacharya A, Kumar M, Ghosal S, Bhattacharya SK. Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats. Phytomedicine. 2000 Apr;7(2):173-175.
Bhattacharya, A. ; Kumar, M. ; Ghosal, S. ; Bhattacharya, S. K. / Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats. In: Phytomedicine. 2000 ; Vol. 7, No. 2. pp. 173-175.
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