Abstract
The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered prophylactically (10, 20 and 50 mg/kg, p.o.) for 10 consecutive day, was found to inhibit acute iron overload (30 mg/kg, i.p.) hepatic lipid peroxidation and the increase of serum levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, used as markers of the induced hepatic dysfunction. A similar effect was produced by silymarin (20 mg/kg, p.o.), an antioxidant hepatoprotective agent. The results support the use of Emblica fruits for hepatoprotection in Ayurveda.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-175 |
| Number of pages | 3 |
| Journal | Phytomedicine |
| Volume | 7 |
| Issue number | 2 |
| State | Published - Apr 2000 |
| Externally published | Yes |
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Keywords
- Antioxidant action
- Emblica officinalis
- Emblicanin A and B
- Iron-induced hepatotoxicity
- Tannoids
ASJC Scopus subject areas
- Plant Science
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats. / Bhattacharya, A.; Kumar, M.; Ghosal, S.; Bhattacharya, S. K.
In: Phytomedicine, Vol. 7, No. 2, 04.2000, p. 173-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats
AU - Bhattacharya, A.
AU - Kumar, M.
AU - Ghosal, S.
AU - Bhattacharya, S. K.
PY - 2000/4
Y1 - 2000/4
N2 - The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered prophylactically (10, 20 and 50 mg/kg, p.o.) for 10 consecutive day, was found to inhibit acute iron overload (30 mg/kg, i.p.) hepatic lipid peroxidation and the increase of serum levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, used as markers of the induced hepatic dysfunction. A similar effect was produced by silymarin (20 mg/kg, p.o.), an antioxidant hepatoprotective agent. The results support the use of Emblica fruits for hepatoprotection in Ayurveda.
AB - The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered prophylactically (10, 20 and 50 mg/kg, p.o.) for 10 consecutive day, was found to inhibit acute iron overload (30 mg/kg, i.p.) hepatic lipid peroxidation and the increase of serum levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, used as markers of the induced hepatic dysfunction. A similar effect was produced by silymarin (20 mg/kg, p.o.), an antioxidant hepatoprotective agent. The results support the use of Emblica fruits for hepatoprotection in Ayurveda.
KW - Antioxidant action
KW - Emblica officinalis
KW - Emblicanin A and B
KW - Iron-induced hepatotoxicity
KW - Tannoids
UR - http://www.scopus.com/inward/record.url?scp=0034068985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034068985&partnerID=8YFLogxK
M3 - Article
VL - 7
SP - 173
EP - 175
JO - Phytomedicine
JF - Phytomedicine
SN - 0944-7113
IS - 2
ER -