Effect of bioactive tannoid principles of Emblica officinalis on iron- induced hepatic toxicity in rats

A. Bhattacharya, M. Kumar, S. Ghosal, S. K. Bhattacharya

Research output: Contribution to journalLetter

40 Scopus citations

Abstract

The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered prophylactically (10, 20 and 50 mg/kg, p.o.) for 10 consecutive day, was found to inhibit acute iron overload (30 mg/kg, i.p.) hepatic lipid peroxidation and the increase of serum levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, used as markers of the induced hepatic dysfunction. A similar effect was produced by silymarin (20 mg/kg, p.o.), an antioxidant hepatoprotective agent. The results support the use of Emblica fruits for hepatoprotection in Ayurveda.

Original languageEnglish (US)
Pages (from-to)173-175
Number of pages3
JournalPhytomedicine
Volume7
Issue number2
DOIs
StatePublished - Apr 2000
Externally publishedYes

Keywords

  • Antioxidant action
  • Emblica officinalis
  • Emblicanin A and B
  • Iron-induced hepatotoxicity
  • Tannoids

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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