TY - JOUR
T1 - Effect of aspirin on angioplasty-induced vessel wall hyperemia
AU - Cragg, A.
AU - Einzig, S.
AU - Rysavy, J.
AU - Castaneda-Zuniga, W.
AU - Borgwardt, B.
AU - Amplatz, K.
PY - 1983
Y1 - 1983
N2 - Angioplasty produces a persistent 20-fold increase in blood flow through mural vasa vasorum. To assess the role of prostaglandins in this phenomenon, vessel wall blood flow in experimentally dilated carotid arteries of aspirin treated dogs was measured. Aspirin (10 mg/kg, intravenously) significantly attenuated the increase in blood flow produced by dilation (+283 ± 91% SE, n = 6) when compared to non-aspirin-treated controls (+2356 ± 885% SE, n = 10). This suggests that aspirin, by interfering with arachidonate metabolism, may decrease local vasodilation after angioplasty. The effect of aspirin therapy on the long-term success of angioplasty requires further study.
AB - Angioplasty produces a persistent 20-fold increase in blood flow through mural vasa vasorum. To assess the role of prostaglandins in this phenomenon, vessel wall blood flow in experimentally dilated carotid arteries of aspirin treated dogs was measured. Aspirin (10 mg/kg, intravenously) significantly attenuated the increase in blood flow produced by dilation (+283 ± 91% SE, n = 6) when compared to non-aspirin-treated controls (+2356 ± 885% SE, n = 10). This suggests that aspirin, by interfering with arachidonate metabolism, may decrease local vasodilation after angioplasty. The effect of aspirin therapy on the long-term success of angioplasty requires further study.
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U2 - 10.2214/ajr.140.6.1233
DO - 10.2214/ajr.140.6.1233
M3 - Article
C2 - 6222639
AN - SCOPUS:0020586039
SN - 0923-2508
VL - 140
SP - 1233
EP - 1238
JO - Research in Microbiology
JF - Research in Microbiology
IS - 6
ER -