Effect of anterior hypothalamic deafferentation and continuous growth hormone infusion on the hepatic synthesis of α(2u)-globulin in the male rat

B. Chatterjee, W. F. Demyan, J. A. Gustafsson, M. W. Harris, T. Hökfelt, G. Norstedt, A. K. Roy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Anterior hypothalamic deafferentation and infusion of human GH (hGH) in the normal male rat caused a marked reduction in the hepatic concentration of α(2u)-globulin, an androgen-dependent protein. Although s.c. injections of hGH (twice-daily) resulted in more than a 50% reduction in the hepatic level of α(2u)-globulin, the same dose of hGH when administered continuously through osmotic minipumps caused a threefold greater inhibition. The decreased hepatic concentration of α(2u)-globulin after hGH administration was associated with corresponding changes in the hepatic level of translatable α(2u)-globulin messenger RNA. Continuous infusion of hGH through osmotic minipumps and removal of the anterior hypothalamic influence on GH secretion by deafferentation also caused a marked reduction in the cytoplasmic androgen-binding activity of the rat liver. These results suggest that alterations in the level and pattern of GH secretion may influence hepatic androgen-binding activity and α(2u)-globulin synthesis.

Original languageEnglish (US)
Pages (from-to)351-355
Number of pages5
JournalJournal of Endocrinology
Volume108
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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