Effect of an intra-uterine device on intracellular relationships of the uterine oestrogen receptor, particularly during pregnancy

L. Myatt, G. Chaudhuri, M. G. Elder, L. Lim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The presence of an intra-uterine device in the rat results in a lower nucleur concentration of the oestrogen receptor in the treated horn at pro-oestrus when it is compared with the contralateral control horn. This effect was also seen after the administration of hyperphysiological doses of oestradiol and when the horn was exposed in vitro to high concentrations of oestradiol. The cyclic changes during the oestrous cycle in the activity of the oestrogen-induced enzyme peroxidase were similar in the treated and control horns. These observations have discounted the possibility that the relatively lower nuclear receptor content in the treated horn at pro-oestrus was due to a decreased exposure to oestrogen. A significantly lower nuclear content was also observed in the treated horn on days 4 and 5 of pregnancy. This was not associated with a deficiency in cytosol receptor content which increased concurrently with that of the control horn in the 6 days of pregnancy that were studied. The proportional content of the putative cytosol factor implicated in receptor translocation was similar in both horns, increasing on days 4 and 6 in concert with reported changes in 'induced protein' synthesis. There appeared to be reduced levels of nuclear receptor at a time when blastocyst implantation normally occurs.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalJournal of Endocrinology
Volume87
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Horns
Estrogen Receptors
Equipment and Supplies
Pregnancy
Estrus
Cytoplasmic and Nuclear Receptors
Cytosol
Estradiol
Estrogens
Activity Cycles
Peroxidase
Enzymes

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effect of an intra-uterine device on intracellular relationships of the uterine oestrogen receptor, particularly during pregnancy. / Myatt, L.; Chaudhuri, G.; Elder, M. G.; Lim, L.

In: Journal of Endocrinology, Vol. 87, No. 3, 1980, p. 357-364.

Research output: Contribution to journalArticle

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