Effect of aging on spontaneous and induced mouse testicular germ cell apoptosis

C. J. Barnes, B. W. Covington IV, I. L. Cameron, M. Lee

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The purpose of this study was to determine whether apoptotic cell death of mouse testicular germ cells varies with increased age, or with exposure to an acute systemic oxidative stress. Results show that the percent of seminiferous tubules with apoptotic cells, and the number of apoptotic cells/tubule cross section were not significantly altered with age. However, there were significantly more apoptotic metaphase spermatocytes at tubule stage XIV in 24-month-old mice than in 6-month-old mice. Oxidative stress significantly increased apoptotic metaphase spermatocytes in young mice, and severely reduced testicular apoptosis in old mice. Our results have potential clinical relevance to changes with increased age in human sperm aneuploidies.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalAging Clinical and Experimental Research
Volume10
Issue number6
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Age
  • Apoptosis
  • Mice
  • Oxidative stress
  • Testis

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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