Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

Govind Rao, Erning Xia, Arlan Richardson

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

Age-related changes in the activities of superoxide dismutase, catalase, and glutathione peroxidase were determined in brain, heart, hepatocytes, intestinal mucosa, and kidney from male Fischer F3444 rats. Superoxide dismutase activity decreased significantly with age in all five tissues studied. The activity of catalase decreased with age in brain, hepatocytes, and kidney while glutathione peroxidase activity decreased significantly with age only in intestinal mucosa and kidney. The relative levels of superoxide dismutase, catalase, and glutathione peroxidase mRNA were measured in brain, hepatocytes, and kidney. An age-related decrease in SOD and catalase mRNA was observed for brain, hepatocytes, and kidney. GPX and mRNA levels decreased with age in hepatocytes and kidney but did not change with age in brain. In general, the age-related changes in the activities of SOD, catalase, and GPX were paralleled by a similar change in the relative level of the mRNAs coding for these enzymes.

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalMechanisms of Ageing and Development
Volume53
Issue number1
DOIs
StatePublished - Mar 31 1990

Keywords

  • Antioxidant enzymes
  • Catalase
  • Gene expression
  • Glutathione peroxidase
  • Superoxide dismutase
  • mRNA

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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