Effect of age and dietary restriction on protein synthesis by isolated kidney cells

Wilbert G. Ricketts, Maria C. Birchenall‐Sparks, James P. Hardwick, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The influence of age and food restriction on kidney protein synthesis was studied in Fischer F344 rats. The rate of total protein synthesis by suspensions of kiney cells declined 60% between 4 and 31 months of age. The rate of protein synthesis by kidney cells isolated from 19‐month old rats fed a restricted diet (60% of diet consumed by rats fed ad libitum) was 45% higher than the rate of protein synthesis by kidney cells isolated from 19‐month old rats fed ad libitum. The excretion of protein in the urine was measured to assess the effect of the age related decline in protein synthesis on kidney function. A dramatic increase in proteinuria was observed with increasing age, and rats fed the restricted diet excreted significantly less protein in the urine than rats fed ad libitum.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalJournal of Cellular Physiology
Volume125
Issue number3
DOIs
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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