Effect of age and dietary restriction on protein synthesis by isolated kidney cells

W. G. Ricketts, M. C. Birchenall-Sparks, J. P. Hardwick, A. Richardson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The influence of age and food restriction on kidney protein synthesis was studied in Fischer F344 rats. The rate of total protein synthesis by suspensions of kidney cells declined 60% between 4 and 31 months of age. The rate of protein synthesis by kidney cells isolated from 19-month old rats fed a restricted diet (60% of diet consumed by rats fed ad libitum) was 45% higher than the rate of protein synthesis by kidney cells isolated from 19-month old rats fed ad libitum. The excretion of protein in the urine was measured to assess the effect of the age related decline in protein synthesis on kidney function. A dramatic increase in proteinuria was observed with increasing age, and rats fed the restricted diet excreted significantly less protein in the urine than rats fed ad libitum.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalJournal of Cellular Physiology
Volume125
Issue number3
StatePublished - 1985
Externally publishedYes

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Rats
Kidney
Nutrition
Proteins
Inbred F344 Rats
Diet
Urine
Proteinuria
Suspensions
Food

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Ricketts, W. G., Birchenall-Sparks, M. C., Hardwick, J. P., & Richardson, A. (1985). Effect of age and dietary restriction on protein synthesis by isolated kidney cells. Journal of Cellular Physiology, 125(3), 492-498.

Effect of age and dietary restriction on protein synthesis by isolated kidney cells. / Ricketts, W. G.; Birchenall-Sparks, M. C.; Hardwick, J. P.; Richardson, A.

In: Journal of Cellular Physiology, Vol. 125, No. 3, 1985, p. 492-498.

Research output: Contribution to journalArticle

Ricketts, WG, Birchenall-Sparks, MC, Hardwick, JP & Richardson, A 1985, 'Effect of age and dietary restriction on protein synthesis by isolated kidney cells', Journal of Cellular Physiology, vol. 125, no. 3, pp. 492-498.
Ricketts WG, Birchenall-Sparks MC, Hardwick JP, Richardson A. Effect of age and dietary restriction on protein synthesis by isolated kidney cells. Journal of Cellular Physiology. 1985;125(3):492-498.
Ricketts, W. G. ; Birchenall-Sparks, M. C. ; Hardwick, J. P. ; Richardson, A. / Effect of age and dietary restriction on protein synthesis by isolated kidney cells. In: Journal of Cellular Physiology. 1985 ; Vol. 125, No. 3. pp. 492-498.
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