Effect of ACTH on biosynthesis of aldosterone and corticosterone by monolayer cultures of rat adrenal zona glomerulosa cells

Peter J. Hornsby, Michael J. O'Hare, A. Munro Neville

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A method is described for preparing monolayer cultures of zona glomerulosa cells isolated from the rat adrenal cortex. Aldosterone and corticosterone were secreted by the cultures when maintained with medium containing 11 mM K+. ACTH, while stimulating aldosterone biosynthesis at first, did not maintain its long-term secretion, yet caused corticosterone production to rise to a steadily maintained level. The significance of this effect is discussed.

Original languageEnglish (US)
Pages (from-to)1554-1559
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume54
Issue number4
DOIs
StatePublished - Oct 15 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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