Effect of a PFOB emulsion (Oxygent) and carbogen breathing on the tumor cell survival of the FSaIIC fibrosarcoma after treatment with antitumor alkylating agents

Sylvia A. Holden, Beverly A. Teicher, Terence S. Herman

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

Many anticancer drugs require oxygen to be cytotoxic or are selectively cytotoxic toward cells under oxygenated conditions. The effects of the dilute perfluorochemical emulsion Fluosol-DA with a wide variety of chemotherapeutic agents have been explored. However, it has not been possible to determine the optimal level of circulating perfluorochemical emulsion with anticancer drugs because of the volume of administration limits with Fluosol-DA. Using a concentrated PFOB emulsion, Oxygent, a wide range of perfluorochemical emulsion doses have been examined in combination with melphalan, cyclophosphamide and BCNU in a murine solid tumor model. When Oxygent was administered by injection i.v. just prior to the injection of melphalan (10 mg/kg) the greatest tumor growth delays were obtained with Oxygent levels between 12 and 20 g PFC/kg. With the drug BCNU (15 mg/kg administered on alternate days for 5 doses) the greatest tumor growth delays were obtained when the drug was prepared in the emulsion and the combination injected i.v. In each case each dose of drug was followed by 6 h of breathing carbogen.

Original languageEnglish (US)
Pages (from-to)399
Number of pages1
JournalBiomaterials, Artificial Cells, and Immobilization Biotechnology
Volume19
Issue number2
StatePublished - 1991
Externally publishedYes
Event8th World Congress of the International Society for Artificial Organs in conjunction with the 4th International Symposium on Blood Substitutes - Montreal, Que, Can
Duration: Aug 19 1991Aug 23 1991

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Effect of a PFOB emulsion (Oxygent) and carbogen breathing on the tumor cell survival of the FSaIIC fibrosarcoma after treatment with antitumor alkylating agents'. Together they form a unique fingerprint.

Cite this