Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro

W. Arlt, P. L.M. Dahia, F. Callies, J. P. Nordmeyer, B. Allolio, A. B. Grossman, M. Reincke

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A desmopressin-induced ACTH increase has been recently suggested to be specific for pituitary-dependent Cushing's disease. We present the case of a 47-year-old woman with Cushing's syndrome due to ectopic ACTH production by a bronchial carcinoid. While CRH failed to induce an ACTH or cortisol response, intravenous administration of desmopressin led to a 47% increase in serum ACTH and a 42% increase in serum cortisol concentration. After surgical removal of the tumour, the desmopressin response became negative. In vitro, ACTH production by tumour cells obtained at surgery was also stimulated by desmopressin but not by CRH. Additional receptor mRNA expression studies using RT-PCR revealed expression of both V2 and V3 vasopressin receptor subtypes in the carcinoid tumour at a level comparable to that recently described in pituitary corticotroph adenomas. This case illustrates that ACTH stimulation by desmopressin is not specific for pituitary-dependent Cushing's syndrome as vasopressin receptor sub-types known to interact with desmopressin may also be found in ectopic tumours producing ACTH.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalClinical Endocrinology
Volume47
Issue number5
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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