@inproceedings{7275293b96fc44f8a0e1c1543a4a4b18,
title = "Economic analysis of centralized vs. decentralized electronic data capture in multi-center clinical studies",
abstract = "Background: New data management models are emerging in multicenter clinical studies. We evaluated the incremental costs associated with decentralized vs. centralized models. Methods: We developed clinical research network economic models to evaluate three data management models: centralized, decentralized with local software, and decentralized with shared database. Descriptive information from three clinical research studies served as inputs for these models. Main Outcome Measures: The primary outcome was total data management costs. Secondary outcomes included: data management costs for sites, local data centers, and central coordinating centers. Results: Both decentralized models were more costly than the centralized model for each clinical research study: the decentralized with local software model was the most expensive. Decreasing the number of local data centers and case book pages reduced cost differentials between models. Conclusion: Decentralized vs. centralized data management in multi-center clinical research studies is associated with increases in data management costs.",
keywords = "Clinical research network, Clinical trial, Cost analysis, Data management",
author = "Anita Walden and Meredith Nahm and Barnett, {M. Edwina} and Conde, {Jose G.} and Andrew Dent and Ahmed Fadiel and Theresa Perry and Chris Tolk and Tcheng, {James E.} and Eisenstein, {Eric L.}",
year = "2011",
doi = "10.3233/978-1-60750-709-3-82",
language = "English (US)",
isbn = "9781607507086",
series = "Studies in Health Technology and Informatics",
publisher = "IOS Press",
pages = "82--88",
booktitle = "International Perspectives in Health Informatics",
}