Eating high-fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning

Michelle G. Baladi, Charles P France

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Discriminative stimulus effects of direct acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high-fat chow increases sensitivity to quinpirole-induced yawning, and this study examined whether eating high-fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high-fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose-response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free-feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high-fat chow is likely because of enhanced sensitivity at D3 receptors. Thus, eating high-fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalBehavioural Pharmacology
Volume21
Issue number7
DOIs
StatePublished - Oct 2010

Fingerprint

Yawning
Quinpirole
Eating
Fats
Reinforcement Schedule
Food
Dopamine Agonists
Pharmaceutical Preparations
Substance-Related Disorders
Shock
Extremities
Discrimination (Psychology)

Keywords

  • Dopamine receptor
  • Drug discrimination
  • High-fat chow
  • Quinpirole
  • Rat
  • Yawning

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Eating high-fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning. / Baladi, Michelle G.; France, Charles P.

In: Behavioural Pharmacology, Vol. 21, No. 7, 10.2010, p. 615-620.

Research output: Contribution to journalArticle

@article{8fee006e844c4698904e3a6124ae2260,
title = "Eating high-fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning",
abstract = "Discriminative stimulus effects of direct acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high-fat chow increases sensitivity to quinpirole-induced yawning, and this study examined whether eating high-fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high-fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose-response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free-feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high-fat chow is likely because of enhanced sensitivity at D3 receptors. Thus, eating high-fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse.",
keywords = "Dopamine receptor, Drug discrimination, High-fat chow, Quinpirole, Rat, Yawning",
author = "Baladi, {Michelle G.} and France, {Charles P}",
year = "2010",
month = "10",
doi = "10.1097/FBP.0b013e32833e7e5a",
language = "English (US)",
volume = "21",
pages = "615--620",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Eating high-fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning

AU - Baladi, Michelle G.

AU - France, Charles P

PY - 2010/10

Y1 - 2010/10

N2 - Discriminative stimulus effects of direct acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high-fat chow increases sensitivity to quinpirole-induced yawning, and this study examined whether eating high-fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high-fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose-response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free-feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high-fat chow is likely because of enhanced sensitivity at D3 receptors. Thus, eating high-fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse.

AB - Discriminative stimulus effects of direct acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high-fat chow increases sensitivity to quinpirole-induced yawning, and this study examined whether eating high-fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high-fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose-response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free-feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high-fat chow is likely because of enhanced sensitivity at D3 receptors. Thus, eating high-fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse.

KW - Dopamine receptor

KW - Drug discrimination

KW - High-fat chow

KW - Quinpirole

KW - Rat

KW - Yawning

UR - http://www.scopus.com/inward/record.url?scp=77957319306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957319306&partnerID=8YFLogxK

U2 - 10.1097/FBP.0b013e32833e7e5a

DO - 10.1097/FBP.0b013e32833e7e5a

M3 - Article

VL - 21

SP - 615

EP - 620

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 7

ER -