Early treatment of candidemia in adults: A review

Luis Ostrosky-Zeichner, Bart Jan Kullberg, Eric J. Bow, Susan Hadley, Cristbal Len, Marcio Nucci, Thomas F Patterson, John R. Perfect

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Invasive candidiasis is associated with high mortality, particularly in adults. Retrospective studies show that shorter times to treatment are correlated with a lower risk of death. A number of factors can be used to predict which patients would benefit from antifungal prophylaxis or early (pre-emptive or empirical) therapy. Detection of the fungal cell wall component (1→3)-β-D-glucan (BDG) shows promise as an early biomarker of invasive fungal infection and may be useful in identifying patients who would benefit from early antifungal treatment. To date, no consistent early treatment strategy has evolved. Proof-of-concept studies are needed to assess the role of pre-emptive and empirical therapy in ICU patients and the relevance of BDG as an early marker of infection.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalMedical Mycology
Volume49
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Candidemia
therapeutics
candidiasis
cell wall components
glucans
retrospective studies
infection
Invasive Candidiasis
biomarkers
disease control
Therapeutics
death
Cellular Structures
Cell Wall
Retrospective Studies
Biomarkers
Mortality
Infection

Keywords

  • Antifungals
  • candidemia
  • empirical therapy
  • invasive candidiasis
  • pre-emptive therapy

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

Cite this

Ostrosky-Zeichner, L., Kullberg, B. J., Bow, E. J., Hadley, S., Len, C., Nucci, M., ... Perfect, J. R. (2011). Early treatment of candidemia in adults: A review. Medical Mycology, 49(2), 113-120. https://doi.org/10.3109/13693786.2010.512300

Early treatment of candidemia in adults : A review. / Ostrosky-Zeichner, Luis; Kullberg, Bart Jan; Bow, Eric J.; Hadley, Susan; Len, Cristbal; Nucci, Marcio; Patterson, Thomas F; Perfect, John R.

In: Medical Mycology, Vol. 49, No. 2, 02.2011, p. 113-120.

Research output: Contribution to journalArticle

Ostrosky-Zeichner, L, Kullberg, BJ, Bow, EJ, Hadley, S, Len, C, Nucci, M, Patterson, TF & Perfect, JR 2011, 'Early treatment of candidemia in adults: A review', Medical Mycology, vol. 49, no. 2, pp. 113-120. https://doi.org/10.3109/13693786.2010.512300
Ostrosky-Zeichner L, Kullberg BJ, Bow EJ, Hadley S, Len C, Nucci M et al. Early treatment of candidemia in adults: A review. Medical Mycology. 2011 Feb;49(2):113-120. https://doi.org/10.3109/13693786.2010.512300
Ostrosky-Zeichner, Luis ; Kullberg, Bart Jan ; Bow, Eric J. ; Hadley, Susan ; Len, Cristbal ; Nucci, Marcio ; Patterson, Thomas F ; Perfect, John R. / Early treatment of candidemia in adults : A review. In: Medical Mycology. 2011 ; Vol. 49, No. 2. pp. 113-120.
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