Early post-stroke depressive symptoms are associated with low peripheral levels of soluble triggering receptor expressed on myeloid cells-1 (Strem-1) and glial cell-derived neurotrophic factor (gdnf)

Vinicius S.P. Pedroso, Érica L.M. Vieira, Aline S. de Miranda, Venugopal R. Venna, Louise D. McCullough, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Stroke is a major cause of death and disability worldwide. Among its com-plications, post-stroke depression (PSD) leads to a significant burden. The diagnosis of PSD is com-plex, and there are no biomarkers that can assist in its early identification and adequate manage-ment. Objective: The aim of the present study is to investigate peripheral biomarkers in the acute phase of stroke and their potential association with depressive symptoms. Methods: We evaluated 60 patients in the acute phase of stroke by using standardized instruments of psychiatric and neurological assessment (Mini International Neuropsychiatric Interview-Plus-MINI-Plus, Hospital Anxiety and Depression Scale-HADS, and National Institutes of Health Stroke Scale-NIHSS) and measured peripheral biomarkers. Results: In multivariate analysis, low peripheral levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and higher NIHSS scores were associated with PSD. The severity of depressive symptoms was inversely correlated with sTREM-1 and glial cell-derived neurotrophic factor (GDNF) levels. Conclusion: This is the first study indicating an association between sTREM-1 and PSD. Our results may point to the involvement of glial mechanisms in the manifestation of depressive symptoms after stroke.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalCurrent Neurovascular Research
Volume17
Issue number4
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Biomarkers
  • Cognitive dysfunction
  • GDNF
  • Post-stroke depression
  • STREM-1
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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