Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans

Niklaus P. Lang, Giovanni E. Salvi, Guy Huynh-ba, Saso Ivanovski, Nikolaos Donos, Dieter D. Bosshardt

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

Objective: To evaluate the rate and degree of osseointegration at chemically modified moderately rough, hydrophilic (SLActive) and moderately rough, hydrophobic (SLA) implant surfaces during early phases of healing in a human model. Material and methods: The devices used for this study of early healing were 4mm long and 2.8mm in diameter and had either an SLActive chemically modified or a moderately rough SLA surface configuration. These devices were surgically installed into the retro-molar area of 49 human volunteers and retrieved after 7, 14, 28 and 42 days of submerged healing. A 5.2-mm-long specially designed trephine with a 4.9mm inside diameter, allowing the circumferential sampling of 1mm tissue together with the device was applied. Histologic ground sections were prepared and histometric analyses of the tissue components (i.e. old bone, new bone, bone debris and soft tissue) in contact with the device surfaces were performed. Results: All device sites healed uneventfully. All device surfaces were partially coated with bone debris. A significant fraction of this bone matrix coating became increasingly covered with newly formed bone. The process of new bone formation started already during the first week in the trabecular regions and increased gradually up to 42 days. The percentage of direct contact between newly formed bone and the device (bone-to-implant contact) after 2 and 4 weeks was more pronounced adjacent to the SLActive than to the SLA surface (14.8% vs. 12.2% and 48.3% vs. 32.4%, respectively), but after 42 days, these differences were no longer evident (61.6% vs. 61.5%). Conclusion: While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalClinical Oral Implants Research
Volume22
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

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Osseointegration
Equipment and Supplies
Bone and Bones
Bone Matrix
Osteogenesis
Volunteers

Keywords

  • Bone-to-implant contact
  • Human
  • Hydrophilic
  • Hydrophobic
  • Implant surfaces
  • Oral implants
  • Osseointegration

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Lang, N. P., Salvi, G. E., Huynh-ba, G., Ivanovski, S., Donos, N., & Bosshardt, D. D. (2011). Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clinical Oral Implants Research, 22(4), 349-356. https://doi.org/10.1111/j.1600-0501.2011.02172.x

Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. / Lang, Niklaus P.; Salvi, Giovanni E.; Huynh-ba, Guy; Ivanovski, Saso; Donos, Nikolaos; Bosshardt, Dieter D.

In: Clinical Oral Implants Research, Vol. 22, No. 4, 04.2011, p. 349-356.

Research output: Contribution to journalArticle

Lang, NP, Salvi, GE, Huynh-ba, G, Ivanovski, S, Donos, N & Bosshardt, DD 2011, 'Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans', Clinical Oral Implants Research, vol. 22, no. 4, pp. 349-356. https://doi.org/10.1111/j.1600-0501.2011.02172.x
Lang, Niklaus P. ; Salvi, Giovanni E. ; Huynh-ba, Guy ; Ivanovski, Saso ; Donos, Nikolaos ; Bosshardt, Dieter D. / Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. In: Clinical Oral Implants Research. 2011 ; Vol. 22, No. 4. pp. 349-356.
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abstract = "Objective: To evaluate the rate and degree of osseointegration at chemically modified moderately rough, hydrophilic (SLActive) and moderately rough, hydrophobic (SLA) implant surfaces during early phases of healing in a human model. Material and methods: The devices used for this study of early healing were 4mm long and 2.8mm in diameter and had either an SLActive chemically modified or a moderately rough SLA surface configuration. These devices were surgically installed into the retro-molar area of 49 human volunteers and retrieved after 7, 14, 28 and 42 days of submerged healing. A 5.2-mm-long specially designed trephine with a 4.9mm inside diameter, allowing the circumferential sampling of 1mm tissue together with the device was applied. Histologic ground sections were prepared and histometric analyses of the tissue components (i.e. old bone, new bone, bone debris and soft tissue) in contact with the device surfaces were performed. Results: All device sites healed uneventfully. All device surfaces were partially coated with bone debris. A significant fraction of this bone matrix coating became increasingly covered with newly formed bone. The process of new bone formation started already during the first week in the trabecular regions and increased gradually up to 42 days. The percentage of direct contact between newly formed bone and the device (bone-to-implant contact) after 2 and 4 weeks was more pronounced adjacent to the SLActive than to the SLA surface (14.8{\%} vs. 12.2{\%} and 48.3{\%} vs. 32.4{\%}, respectively), but after 42 days, these differences were no longer evident (61.6{\%} vs. 61.5{\%}). Conclusion: While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface.",
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