Early onset pancreatic malignancies: Clinical characteristics and survival associations

Alicia Beeghly-Fadiel, Hung N. Luu, Liping Du, Chanjuan Shi, Dauphne P. McGavic, Alexander A. Parikh, Leon Raskin

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Diagnosed before age 50, early onset pancreatic malignancy (EOPM), is hypothesized to be a distinct subset of disease, although research is limited. To better characterize EOPM, and the effect of age at diagnosis on pancreatic cancer survival, we examined clinical characteristics and survival in EOPM and typical age-at-onset pancreatic malignancy (TOPM) cases. Vanderbilt University Medical Center (VUMC) Cancer Registry confirmed pancreatic adenocarcinomas (PDACs) and malignant pancreatic neuroendocrine tumors (PNETs) were evaluated. Clinical characteristics were compared using χ2 tests. Overall survival was visualized with Kaplan–Meier functions; Cox proportional hazards regression was used to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 1,697 pancreatic malignancies were diagnosed at the VUMC between 1988 and 2013. Of 1,407 PDACs, 118 (8.4%) were EOPM, which was associated with significantly better survival (adjusted HR: 0.82, 95% CI: 0.67–1.00). EOPM and TOPM PDACs significantly differed with regard to having multiple malignancies; survival associations significantly differed by race, stage of disease, treatment and multiple malignancies. Of 190 PNETs, 63 (33.1%) were EOPM, which was not significantly associated with survival (adjusted HR: 0.80, 95% CI: 0.46–1.40). Malignant neuroendocrine EOPM and TOPM cases significantly differed by stage of disease and tumor location; survival associations significantly differed by family history of pancreatic cancer, stage of disease and multiple malignancies. Differences in clinical characteristics and associations with survival were identified, indicating that EOPM is distinct from TOPM, and exists among both pancreatic adenocarcinomas and malignant pancreatic neuroendocrine tumors.

Original languageEnglish (US)
Pages (from-to)2169-2177
Number of pages9
JournalInternational Journal of Cancer
Volume139
Issue number10
DOIs
StatePublished - Nov 15 2016
Externally publishedYes

Keywords

  • PDAC
  • PNET
  • early onset
  • pancreatic cancer
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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