Abstract
Background: The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. Methods: Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Organ Sharing. Results: Among 64,977 who underwent liver transplantation, the incidence of 90-day and 1-year mortality was 5% and 10%, respectively. Although death associated with cardiovascular/cerebrovascular/pulmonary/hemorrhage was the most cause of death within the first 21 days (7-day: 53%), only 20% of liver transplantation patients died from these causes after 180 days. Infections were the most frequent cause of death during 30–180 days after liver transplantation. In contrast, after roughly 200 days from the time of liver transplantation, other causes of death were the most frequent cause of death. Although patients with autoimmune hepatitis, nonalcoholic steatohepatitis, and alcoholic cirrhosis had a similar risk of 1-year mortality, patients undergoing liver transplantation for viral hepatitis and hepatocellular carcinoma had an increased risk of 1-year mortality (viral: OR 1.56; hepatocellular carcinoma: OR 1.57; P <.001). Conclusion: Roughly, 1 in 10 patients died within the first year after liver transplantation. The cause of death had a notable, time-specific variation over the first year after liver transplantation.
| Original language | English (US) |
|---|---|
| Journal | Surgery (United States) |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Surgery
Cite this
Early mortality after liver transplantation : Defining the course and the cause. / Baganate, Fabio; Beal, Eliza W.; Tumin, Dmitry; Azoulay, Daniel; Mumtaz, Khalid; Black, Sylvester M.; Washburn, Kenneth; Pawlik, Timothy M.
In: Surgery (United States), 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early mortality after liver transplantation
T2 - Defining the course and the cause
AU - Baganate, Fabio
AU - Beal, Eliza W.
AU - Tumin, Dmitry
AU - Azoulay, Daniel
AU - Mumtaz, Khalid
AU - Black, Sylvester M.
AU - Washburn, Kenneth
AU - Pawlik, Timothy M.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. Methods: Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Organ Sharing. Results: Among 64,977 who underwent liver transplantation, the incidence of 90-day and 1-year mortality was 5% and 10%, respectively. Although death associated with cardiovascular/cerebrovascular/pulmonary/hemorrhage was the most cause of death within the first 21 days (7-day: 53%), only 20% of liver transplantation patients died from these causes after 180 days. Infections were the most frequent cause of death during 30–180 days after liver transplantation. In contrast, after roughly 200 days from the time of liver transplantation, other causes of death were the most frequent cause of death. Although patients with autoimmune hepatitis, nonalcoholic steatohepatitis, and alcoholic cirrhosis had a similar risk of 1-year mortality, patients undergoing liver transplantation for viral hepatitis and hepatocellular carcinoma had an increased risk of 1-year mortality (viral: OR 1.56; hepatocellular carcinoma: OR 1.57; P <.001). Conclusion: Roughly, 1 in 10 patients died within the first year after liver transplantation. The cause of death had a notable, time-specific variation over the first year after liver transplantation.
AB - Background: The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. Methods: Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Organ Sharing. Results: Among 64,977 who underwent liver transplantation, the incidence of 90-day and 1-year mortality was 5% and 10%, respectively. Although death associated with cardiovascular/cerebrovascular/pulmonary/hemorrhage was the most cause of death within the first 21 days (7-day: 53%), only 20% of liver transplantation patients died from these causes after 180 days. Infections were the most frequent cause of death during 30–180 days after liver transplantation. In contrast, after roughly 200 days from the time of liver transplantation, other causes of death were the most frequent cause of death. Although patients with autoimmune hepatitis, nonalcoholic steatohepatitis, and alcoholic cirrhosis had a similar risk of 1-year mortality, patients undergoing liver transplantation for viral hepatitis and hepatocellular carcinoma had an increased risk of 1-year mortality (viral: OR 1.56; hepatocellular carcinoma: OR 1.57; P <.001). Conclusion: Roughly, 1 in 10 patients died within the first year after liver transplantation. The cause of death had a notable, time-specific variation over the first year after liver transplantation.
UR - http://www.scopus.com/inward/record.url?scp=85050694578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050694578&partnerID=8YFLogxK
U2 - 10.1016/j.surg.2018.04.039
DO - 10.1016/j.surg.2018.04.039
M3 - Article
AN - SCOPUS:85050694578
JO - Surgery (United States)
JF - Surgery (United States)
SN - 0039-6060
ER -