TY - JOUR
T1 - Early Gene Expression in Salivary Gland after Isoproterenol Treatment
AU - Zhou, Yi
AU - Chen, Hung I.H.
AU - Lin, Al
AU - Dang, H.
AU - Haack, Karin
AU - Cole, Shelley A.
AU - Huang, Yufei
AU - Yu, Haiyang
AU - Chen, Yidong
AU - Yeh, Chih Ko
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Isoproterenol, a β-adrenergic agonist, has been shown to induce salivary gland hyperplasia. However, the mechanism involved in this pharmacological phenomenon is not well understood. To gain a better understanding of the underlying changes, including genes, networks and pathways altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 min after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. Pathway analysis showed that cell hyperplasia, p38MAPK, and IGF-1 were the most altered function, network and pathway, respectively. The balanced regulation of up- and down-expression of genes related to cell proliferation/survival may provide a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement without tumor transformation. J. Cell. Biochem. 116: 431-437, 2015.
AB - Isoproterenol, a β-adrenergic agonist, has been shown to induce salivary gland hyperplasia. However, the mechanism involved in this pharmacological phenomenon is not well understood. To gain a better understanding of the underlying changes, including genes, networks and pathways altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 min after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. Pathway analysis showed that cell hyperplasia, p38MAPK, and IGF-1 were the most altered function, network and pathway, respectively. The balanced regulation of up- and down-expression of genes related to cell proliferation/survival may provide a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement without tumor transformation. J. Cell. Biochem. 116: 431-437, 2015.
KW - MAPK pathway
KW - gene ontology and pathway analysis
KW - parotid gland enlargement
KW - β-adrenergic receptor
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U2 - 10.1002/jcb.24995
DO - 10.1002/jcb.24995
M3 - Article
C2 - 25336019
AN - SCOPUS:84943534043
SN - 0730-2312
VL - 116
SP - 431
EP - 437
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
IS - 3
ER -