Early Gene Expression in Salivary Gland after Isoproterenol Treatment

Yi Zhou, Hung I.H. Chen, Al Lin, H. Dang, Karin Haack, Shelley A. Cole, Yufei Huang, Haiyang Yu, Yidong Chen, Chih Ko Yeh

Research output: Contribution to journalArticle

Abstract

Isoproterenol, a β-adrenergic agonist, has been shown to induce salivary gland hyperplasia. However, the mechanism involved in this pharmacological phenomenon is not well understood. To gain a better understanding of the underlying changes, including genes, networks and pathways altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 min after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. Pathway analysis showed that cell hyperplasia, p38MAPK, and IGF-1 were the most altered function, network and pathway, respectively. The balanced regulation of up- and down-expression of genes related to cell proliferation/survival may provide a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement without tumor transformation. J. Cell. Biochem. 116: 431-437, 2015.

Original languageEnglish (US)
Pages (from-to)431-437
Number of pages7
JournalJournal of Cellular Biochemistry
Volume116
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • MAPK pathway
  • gene ontology and pathway analysis
  • parotid gland enlargement
  • β-adrenergic receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Zhou, Y., Chen, H. I. H., Lin, A., Dang, H., Haack, K., Cole, S. A., Huang, Y., Yu, H., Chen, Y., & Yeh, C. K. (2015). Early Gene Expression in Salivary Gland after Isoproterenol Treatment. Journal of Cellular Biochemistry, 116(3), 431-437. https://doi.org/10.1002/jcb.24995