Early changes in adipokines from overweight to obesity in children and adolescents

Rafael Machado Mantovani, Natália Pessoa Rocha, Daniel Massote Magalhães, Izabela Guimarães Barbosa, Antônio Lúcio Teixeira, Ana Cristina Simões e Silva

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective Childhood obesity has been associated with metabolic syndrome and cardiovascular diseases. This study aimed to compare plasma levels of traditional metabolic markers, adipokines and soluble tumor necrosis factor receptor type 1 (sTNFR1) in overweight, obese and lean children. We also assessed the relationships of these molecules with classical metabolic risk factors. Methods This study included 104 children and adolescents, which were grouped as: lean (n = 24), overweight (n = 30), and obese subjects (n = 50). They were subjected to anthropometrical, clinical and laboratorial measurements. All measurements were compared between groups. Correlation analyses were also performed to evaluate the association between clinical data, traditional metabolic markers, adipokines and sTNFR1. Results Fasting glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), LDL-cholesterol and triglycerides were comparable in lean, overweight and obese subjects. Plasma levels of sTNFR1 were similar in lean and overweight subjects, but significantly increased in obese group. Leptin, adiponectin and resistin levels did not differ when overweight were compared to obese subjects. However, all adipokines differed significantly when lean subjects were compared to overweight and obese individuals. Plasma levels of adiponectin were negatively correlated with body mass index (BMI), whereas leptin, resistin and sTNFR1 concentrations positively correlated with BMI. Conclusion Our results showed significant differences in circulating levels of the evaluated markers when lean, overweight and obese individuals were compared, suggesting that these biomarkers may change from lean to overweight and from overweight to obesity.

Original languageEnglish (US)
Pages (from-to)624-630
Number of pages7
JournalJornal de Pediatria
Issue number6
StatePublished - Nov 1 2016
Externally publishedYes


  • Adiponectin
  • Leptin
  • Metabolic markers
  • Resistin
  • Soluble tumor necrosis factor receptor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Early changes in adipokines from overweight to obesity in children and adolescents'. Together they form a unique fingerprint.

Cite this