Dyskeratosis congenita, telomeres and human ageing

Robert A. Marciniak; F. Brad Johnson; Leonard Guarente

doi:10.1016/S0168-9525(00)01984-3

Dyskeratosis congenita, telomeres and human ageing

Robert A. Marciniak, F. Brad Johnson, Leonard Guarente

Research output: Contribution to journal › Short survey › peer-review

47 Scopus citations

Abstract

As normal humans age, telomeres shorten in tissues that contain dividing cells, and this has been proposed both as a cause of ageing and as a tumor-suppressor mechanism. The surprising finding that cells from individuals with the rare inherited disorder dyskeratosis congenita (DKC) have reduced levels of telomerase and shortened telomeres might provide the first direct genetic test of the function of telomeres in intact humans. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	193-195
Number of pages	3
Journal	Trends in Genetics
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/S0168-9525(00)01984-3
State	Published - May 1 2000
Externally published	Yes

ASJC Scopus subject areas

Genetics

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AU - Guarente, Leonard

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AB - As normal humans age, telomeres shorten in tissues that contain dividing cells, and this has been proposed both as a cause of ageing and as a tumor-suppressor mechanism. The surprising finding that cells from individuals with the rare inherited disorder dyskeratosis congenita (DKC) have reduced levels of telomerase and shortened telomeres might provide the first direct genetic test of the function of telomeres in intact humans. Copyright (C) 2000 Elsevier Science Ltd.

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Dyskeratosis congenita, telomeres and human ageing

Abstract

ASJC Scopus subject areas

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