Dyskeratosis congenita, telomeres and human ageing

Robert A. Marciniak, F. Brad Johnson, Leonard Guarente

Research output: Contribution to journalShort surveypeer-review

47 Scopus citations


As normal humans age, telomeres shorten in tissues that contain dividing cells, and this has been proposed both as a cause of ageing and as a tumor-suppressor mechanism. The surprising finding that cells from individuals with the rare inherited disorder dyskeratosis congenita (DKC) have reduced levels of telomerase and shortened telomeres might provide the first direct genetic test of the function of telomeres in intact humans. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalTrends in Genetics
Issue number5
StatePublished - May 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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