Dynamic changes in the cerebral metabolic rate of O2 and oxygen extraction ratio in event-related functional MRI

Ching Mei Feng; Ho Ling Liu; Peter T. Fox; Jia Hong Gao

doi:10.1016/S1053-8119(02)00023-X

Dynamic changes in the cerebral metabolic rate of O₂ and oxygen extraction ratio in event-related functional MRI

Ching Mei Feng, Ho Ling Liu, Peter T. Fox, Jia Hong Gao

Department of Radiology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Dynamic changes in the cerebral metabolic rate of oxygen (CMRO₂) and oxygen extraction ratio (OER) in an event-related functional MRI (ER-fMRI) were measured in this study. Six subjects participated in this study at a magnetic field of 1.9 T. Cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) changes were acquired during the brief visual stimulation, and the corresponding changes in CMRO₂ and OER were then determined. The results showed that the maximum relative changes in CMRO₂ and OER were about 10.36 ± 0.85 and -6.54 ± 0.55%, respectively, while the maximum changes in CBF and BOLD were approximately 17.35 ± 1.37 and 1.03 ± 0.06%, respectively. The CBF, CMRO₂, and OER changes reach their maximum approximately 1 s earlier than the BOLD signal change (4.15 ± 0.21, 4.16 ± 0.21, and 4.17 ± 0.21 s vs 5.12 ± 0.24 s after stimulation, P < 0.05).

Original language	English (US)
Pages (from-to)	257-262
Number of pages	6
Journal	NeuroImage
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/S1053-8119(02)00023-X
State	Published - Feb 1 2003

Keywords

Blood oxygenation level-dependent
Cerebral blood flow
Cerebral metabolic rate of oxygen
Magnetic resonance imaging
Oxygen extraction ratio

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

Access to Document

10.1016/S1053-8119(02)00023-X

Cite this

@article{e35ff589736b436bb1faebbb8865bc6a,

title = "Dynamic changes in the cerebral metabolic rate of O2 and oxygen extraction ratio in event-related functional MRI",

abstract = "Dynamic changes in the cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction ratio (OER) in an event-related functional MRI (ER-fMRI) were measured in this study. Six subjects participated in this study at a magnetic field of 1.9 T. Cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) changes were acquired during the brief visual stimulation, and the corresponding changes in CMRO2 and OER were then determined. The results showed that the maximum relative changes in CMRO2 and OER were about 10.36 ± 0.85 and -6.54 ± 0.55%, respectively, while the maximum changes in CBF and BOLD were approximately 17.35 ± 1.37 and 1.03 ± 0.06%, respectively. The CBF, CMRO2, and OER changes reach their maximum approximately 1 s earlier than the BOLD signal change (4.15 ± 0.21, 4.16 ± 0.21, and 4.17 ± 0.21 s vs 5.12 ± 0.24 s after stimulation, P < 0.05).",

keywords = "Blood oxygenation level-dependent, Cerebral blood flow, Cerebral metabolic rate of oxygen, Magnetic resonance imaging, Oxygen extraction ratio",

author = "Feng, {Ching Mei} and Liu, {Ho Ling} and Fox, {Peter T.} and Gao, {Jia Hong}",

note = "Funding Information: This work was supported by NIH Grants AG19844, MH52176, NS37109, and MH60246.",

year = "2003",

month = feb,

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doi = "10.1016/S1053-8119(02)00023-X",

language = "English (US)",

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T1 - Dynamic changes in the cerebral metabolic rate of O2 and oxygen extraction ratio in event-related functional MRI

AU - Feng, Ching Mei

AU - Liu, Ho Ling

AU - Fox, Peter T.

AU - Gao, Jia Hong

N1 - Funding Information: This work was supported by NIH Grants AG19844, MH52176, NS37109, and MH60246.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Dynamic changes in the cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction ratio (OER) in an event-related functional MRI (ER-fMRI) were measured in this study. Six subjects participated in this study at a magnetic field of 1.9 T. Cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) changes were acquired during the brief visual stimulation, and the corresponding changes in CMRO2 and OER were then determined. The results showed that the maximum relative changes in CMRO2 and OER were about 10.36 ± 0.85 and -6.54 ± 0.55%, respectively, while the maximum changes in CBF and BOLD were approximately 17.35 ± 1.37 and 1.03 ± 0.06%, respectively. The CBF, CMRO2, and OER changes reach their maximum approximately 1 s earlier than the BOLD signal change (4.15 ± 0.21, 4.16 ± 0.21, and 4.17 ± 0.21 s vs 5.12 ± 0.24 s after stimulation, P < 0.05).

AB - Dynamic changes in the cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction ratio (OER) in an event-related functional MRI (ER-fMRI) were measured in this study. Six subjects participated in this study at a magnetic field of 1.9 T. Cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) changes were acquired during the brief visual stimulation, and the corresponding changes in CMRO2 and OER were then determined. The results showed that the maximum relative changes in CMRO2 and OER were about 10.36 ± 0.85 and -6.54 ± 0.55%, respectively, while the maximum changes in CBF and BOLD were approximately 17.35 ± 1.37 and 1.03 ± 0.06%, respectively. The CBF, CMRO2, and OER changes reach their maximum approximately 1 s earlier than the BOLD signal change (4.15 ± 0.21, 4.16 ± 0.21, and 4.17 ± 0.21 s vs 5.12 ± 0.24 s after stimulation, P < 0.05).

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KW - Cerebral blood flow

KW - Cerebral metabolic rate of oxygen

KW - Magnetic resonance imaging

KW - Oxygen extraction ratio

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